Evidence map›Paper›PMID 39188570›Full record

ArticleFrontiers in cellular neuroscience2024

Mitochondrial stress-induced H4K12 hyperacetylation dysregulates transcription in Parkinson's disease.

Minhong Huang, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G Kanthasamy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Minhong HuangParkinson Disorders Research Laboratory, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA, United States.
Huajun JinIsakson Center for Neurological Disease Research, Department of Physiology and Pharmacology, University of Georgia, Athens, GA, United States.
Vellareddy AnantharamIsakson Center for Neurological Disease Research, Department of Physiology and Pharmacology, University of Georgia, Athens, GA, United States.
Arthi KanthasamyIsakson Center for Neurological Disease Research, Department of Physiology and Pharmacology, University of Georgia, Athens, GA, United States.
Anumantha G KanthasamyParkinson Disorders Research Laboratory, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA, United States.

Funding

Protein Aggregation and Inflammasome Signaling in Manganese Neurotoxicity.R01ES026892 · NIEHS · UNIVERSITY OF GEORGIA · PI KANTHASAMY, ANUMANTHA GOUNDER · 2016 to 2020
$2.0M
The Role of KCa3.1 in Microglial function and in Parkinsons disease pathogenesisR01NS124226 · NINDS · UNIVERSITY OF GEORGIA · PI ARTHI KANTHASAMY, HEIKE WULFF · 2021 to 2026
$1.9M
Neuroinflammation and microglial Kv1.3 in Parkinsons diseaseR01NS100090 · NINDS · UNIVERSITY OF GEORGIA · PI KANTHASAMY, ANUMANTHA GOUNDER · 2017 to 2021
$1.9M
Novel Mechanisms of Pesticide-Induced NeurotoxicityR01ES027245 · NIEHS · UNIVERSITY OF GEORGIA · PI KANTHASAMY, ANUMANTHA GOUNDER · 2017 to 2021
$1.7M
Novel Re-engineered L DOPA probiotic therapy for Parkinsons DiseaseR61NS112441 · NINDS · UNIVERSITY OF GEORGIA · PI KANTHASAMY, ANUMANTHA GOUNDER · 2020 to 2020
$387k
NIEHS NIH HHS R01 ES026892NIEHS NIH HHS R01 ES027245NINDS NIH HHS R01 NS100090NINDS NIH HHS R01 NS124226NINDS NIH HHS R61 NS112441
6 · The paper itself

Abstract

Aberrant epigenetic modification has been implicated in the pathogenesis of Parkinson's disease (PD), which is characterized by the irreversible loss of dopaminergic (DAergic) neurons. However, the mechanistic landscape of histone acetylation (ac) in PD has yet to be fully explored. Herein, we mapped the proteomic acetylation profiling changes at core histones H4 and thus identified H4K12ac as a key epigenomic mark in dopaminergic neuronal cells as well as

Indexed as

acetylationagingbiomarkerepigenomicsmitochondrial dysfunctionParkinson patients

Identifiers

PMID39188570
PMCPMC11345260

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.