Evidence map›Paper›PMID 39188554›Full record

ReviewSmart medicine2023

Nurturing the marriages of urinary liquid biopsies and nano-diagnostics for precision urinalysis of prostate cancer.

Caizhi Liao, Zhihao Wu, Chan Lin, Xiaofeng Chen, Yaqun Zou, Wan Zhao, Xin Li, Guangqi Huang, Baisheng Xu, Giovanni E Briganti and 5 more

Abstract readReview
In one paragraph

Review in Smart medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Caizhi LiaoCreative Biosciences (Guangzhou) Co., Ltd Guangzhou China.ORCID https://orcid.org/0000-0003-1271-3027
Zhihao WuCreative Biosciences (Guangzhou) Co., Ltd Guangzhou China.
Chan LinCreative Biosciences (Guangzhou) Co., Ltd Guangzhou China.
Xiaofeng ChenSchool of Environmental and Geographical Sciences Shanghai Normal University Shanghai China.
Yaqun ZouCreative Biosciences (Guangzhou) Co., Ltd Guangzhou China.
Wan ZhaoCreative Biosciences (Guangzhou) Co., Ltd Guangzhou China.
Xin LiDepartment of Urology Sir Run Run Shaw Hospital Zhejiang University Hangzhou China.
Guangqi HuangPeking University Health Science Center Beijing China.
Baisheng XuDepartment of Urology The First People's Hospital of Xiushui Jiujiang China.
Giovanni E BrigantiDepartment of Urology University of Florence Florence Italy.
Yan QiCreative Biosciences (Guangzhou) Co., Ltd Guangzhou China.
Xianshu WangCreative Biosciences (Guangzhou) Co., Ltd Guangzhou China.
Tao ZengDepartment of Urology the Second Affiliated Hospital of Nanchang University Nanchang China.
Alain WuethrichCentre for Personalised Nanomedicine, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland Brisbane Queensland Australia.
Hongzhi ZouCreative Biosciences (Guangzhou) Co., Ltd Guangzhou China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prostate cancer remains the second-most common cancer diagnosed in men, despite the increasingly widespread use of serum prostate-specific antigen (PSA) screening. The controversial clinical implications and cost benefits of PSA screening have been highlighted due to its poor specificity, resulting in a high rate of overdiagnosis and underdiagnosis. Thus, the development of novel biomarkers for prostate cancer detection remains an intriguing challenge. Urine is emerging as a source for prostate cancer biomarker discovery. Currently, new urine biomarkers already outperform serum PSA in clinical diagnosis. Meanwhile, the advances in nanotechnology have provided a suite of diagnostic tools to study prostate cancer in more detail, sparking a new era of biomarker discoveries. In this review, we envision that future prostate cancer diagnosis will probably integrate multiplex nano-diagnostic approaches to detect novel urinary biomarkers. However, challenges remain in differentiating indolent from aggressive cancers to better inform treatment decisions, and clinical translation still needs to be overcome.

Indexed as

nano diagnosticsnanomaterialprostate cancer (PCa)urinary biomarkerurinary liquid biopsy

Identifiers

PMID39188554
PMCPMC11236013

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.