Evidence map›Paper›PMID 39188380›Full record

ArticleBioactive materials2024

Personalized composite scaffolds for accelerated cell- and growth factor-free craniofacial bone regeneration.

Mirae Kim, Xinlong Wang, Yiming Li, Zitong Lin, Caralyn P Collins, Yugang Liu, Yujin Ahn, Hsiu-Ming Tsal, Joseph W Song, Chongwen Duan and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Mirae KimDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA.
Xinlong WangDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA.
Yiming LiDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
Zitong LinDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
Caralyn P CollinsCenter for Advanced Regenerative Engineering, Northwestern University, Evanston, IL, 60208, USA.
Yugang LiuDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA.
Yujin AhnDepartment of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, 61820, USA.
Hsiu-Ming TsalDepartment of Radiology, The University of Chicago, Chicago, IL, 60637, USA.
Joseph W SongDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA.
Chongwen DuanDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA.
Yi ZhuMolecular Oncology Laboratory, Department of Orthopedic Surgery and Rehabilitation Medicine, The University of Chicago Medical Center, Chicago, IL, 60637, USA.
Cheng SunCenter for Advanced Regenerative Engineering, Northwestern University, Evanston, IL, 60208, USA.
Tong-Chuan HeCenter for Advanced Regenerative Engineering, Northwestern University, Evanston, IL, 60208, USA.
Yuan LuoDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
Russell R ReidCenter for Advanced Regenerative Engineering, Northwestern University, Evanston, IL, 60208, USA.
Guillermo A AmeerDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA.

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9M
Multi-Tissue Craniofacial Engineering using 3D-BMP9-Notch-Synergized Graphene Citrate Composite ScaffoldsR01DE030480 · NIDCR · UNIVERSITY OF CHICAGO · PI REID, RUSSELL R. · 2021 to 2025
$2.3M
NCI NIH HHS P30 CA060553NIDCR NIH HHS R01 DE030480
6 · The paper itself

Abstract

Approaches to regenerating bone often rely on integrating biomaterials and biological signals in the form of cells or cytokines. However, from a translational point of view, these approaches are challenging due to the sourcing and quality of the biologic, unpredictable immune responses, complex regulatory paths, and high costs. We describe a simple manufacturing process and a material-centric 3D-printed composite scaffold system (CSS) that offers distinct advantages for clinical translation. The CSS comprises a 3D-printed porous polydiolcitrate-hydroxyapatite composite elastomer infused with a polydiolcitrate-graphene oxide hydrogel composite. Using a micro-continuous liquid interface production 3D printer, we fabricate a precise porous ceramic scaffold with 60 wt% hydroxyapatite resembling natural bone. The resulting scaffold integrates with a thermoresponsive hydrogel composite

Indexed as

3D printingCitrate biomaterialComposite scaffoldCraniofacial bone regenerationMaterial-centric approach

Identifiers

PMID39188380
PMCPMC11345904

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.