Evidence map›Paper›PMID 39188362›Full record

ArticleMolecular therapy. Oncology2024

Journey through tumorverse: Creating models to decode PXA mysteries.

George Bukenya, Anthony R Sloan, Justin D Lathia

Abstract readNews
In one paragraph

Article in Molecular therapy. Oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

George BukenyaLerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Anthony R SloanLerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Justin D LathiaLerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.

Funding

Sex-specific differences in the tumor microenvironment alter glioblastoma growthP01CA245705 · NCI · CLEVELAND CLINIC LERNER COM-CWRU · PI Jingqin Luo · 2020 to 2026
$15.0M
RESEARCH ONCOLOGY TRAINING GRANTT32CA059366 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI JACKSON, MARK W. · 1993 to 2025
$5.5M
Contribution of Myeloid-Derived Suppressor Cells to Neuro-Inflammatory Alterations and Disease Progression in GlioblastomaR35NS127083 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI Justin D. Lathia · 2022 to 2026
$3.1M
Microglial Activation and Inflammatory Endophenotypes Underlying Sex Differences of Alzheimer’s DiseaseR01AG084250 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI Feixiong Cheng, Justin D. Lathia · 2023 to 2026
$2.2M
A Hyper-Thrombotic State and Immunosuppression in GBMF32CA287655 · NCI · CLEVELAND CLINIC LERNER COM-CWRU · PI Anthony Robert Sloan · 2024 to 2026
$155k
NCI NIH HHS F32 CA287655NCI NIH HHS P01 CA245705NCI NIH HHS T32 CA059366NIA NIH HHS R01 AG084250NINDS NIH HHS R35 NS127083
6 · The paper itself

Abstract

Pleomorphic xanthoastrocytoma (PXA) is a rare pediatric low-grade glioma (pLGG), of which 60%-80% exhibit the BRAF V600E mutation, that enhances the aggressiveness and progression to an eventual pediatric high-grade glioma (pHGG). Despite the aggressiveness of this mutational status, the mechanisms underlying the progression of BRAF V600E tumors remain poorly understood, primarily due to limited insights into their

Identifiers

PMID39188362
PMCPMC11347045

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.