A maverick: Environmentally relevant concentrations of nonylphenol attenuate the plasmid-mediated conjugative transfer of antibiotic resistance genes.

Si-Zhou Liang, Ya-Jun Chang, Philip Semaha, Li-Zhu Liu, Yan Gao, Zhi Wang, Wei-Guo Zhang

Abstract read

In one paragraph

Article in Water research X, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Si-Zhou LiangChina Ministry of Agriculture Key Laboratory at Yangtze River Plain for Agricultural Environment, Institute of Agricultural Resources and Environment, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China.

Ya-Jun ChangJiangsu Key Laboratory for the Research and Utilization of Plant Resources, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences (Nanjing Botanical Garden Memorial Sun Yat-Sen), Nanjing 210014, China.

Philip SemahaDepartment of Agriculture, Ministry of Local Government and Rural Development, AJ 2, Ajumako, Central Region, Ghana.

Li-Zhu LiuChina Ministry of Agriculture Key Laboratory at Yangtze River Plain for Agricultural Environment, Institute of Agricultural Resources and Environment, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China.

Yan GaoChina Ministry of Agriculture Key Laboratory at Yangtze River Plain for Agricultural Environment, Institute of Agricultural Resources and Environment, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China.

Zhi WangInnovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan 430071, China.

Wei-Guo ZhangChina Ministry of Agriculture Key Laboratory at Yangtze River Plain for Agricultural Environment, Institute of Agricultural Resources and Environment, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Given that many organic pollutants have been reported to facilitate the plasmid-mediated conjugative transfer of antibiotic resistance genes (ARGs), it was naturally deduced that nonylphenol (NP) can also have this kind of effect. Whereas, this study demonstrates an entirely different result that environmentally relevant concentrations of NP attenuate plasmid-mediated ARGs conjugative transfer (maximum inhibition rate 64 %), further study show that NP exposure had no significant effect on bacterial growth, cell vitality, oxidative stress response, and expression of conjugation-relevant genes, which were reported to closely relate to the conjugative transfer in numerous studies. Conclusively, it was found that the dispersant function of NP impeded the occurrence of cell mating, thus was responsible for the decline of conjugative transfer. This study shows a new perspective on understanding the effect of organic pollutants like NP on the ARGs horizontal dissemination in environment.

Indexed as

Antibiotic resistance genesConjugative transferNonylphenolPublic health

Identifiers

PMID39188327

DOI10.1016/j.wroa.2024.100241

PMCPMC11345678

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.