ArticleFrontiers in cardiovascular medicine2024
The relationship between system inflammation response index and coronary heart disease: a cross-sectional study (NHANES 2007-2016).
Article in Frontiers in cardiovascular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed.
- Association between albumin-bilirubin score and gallstones: exploring the potential mediating role of body mass index based on NHANES 2017-2020.Internal and emergency medicine · 2026Article
- Multi-omics analyses reveal novel metabolic signatures of post-traumatic deep vein thrombosis in patients with coronary heart disease.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Inflammation at the crossroads of reproduction: SIRI as a prognostic signature of female infertility in hybrid regression-machine learning models.Archives of gynecology and obstetrics · 2026Article
- Serum albumin and hypertension: The mediating roles of BMI, C-reactive protein and extracellular fluid.Asia Pacific journal of clinical nutrition · 2026Article
- Predictive value of systemic inflammation response index for atherosclerotic cardiovascular disease risk in patients with hypercholesterolemia: a machine learning study with dual-cohort validation.Lipids in health and disease · 2025Article
- Association between novel Immune-Inflammatory markers and hypertension patients with coronary heart disease: A Cross-Sectional study based on NHANES (2005-2016).BMC cardiovascular disorders · 2025Article
- Non-linear association between extracellular water/total body water ratio and all-cause mortality: a population-based cohort study.Scientific reports · 2025Article
- Association between monocyte-to-lymphocyte ratio and cardiovascular diseases: insights from NHANES data.Diabetology & metabolic syndrome · 2025Article
- Construction of diagnostic and prognostic models for premature coronary artery disease based on multiple machine algorithms.Frontiers in cardiovascular medicine · 2025Article
- Relationship between inflammatory markers and long-term prognosis in ICU patients with acute non-ST-segment elevation myocardial infarction.Frontiers in cardiovascular medicine · 2025Article
- Yiqi Huoxue Tongluo decoction combined with conventional medicine therapy: effects on restenosis rates and clinical efficacy in patients with coronary heart disease undergoing percutaneous coronary intervention.Frontiers in cardiovascular medicine · 2025Article
- TyG index and CBC-derived inflammatory indicators individual and mixed effects on all-cause and cardiovascular disease deaths in patients with CHD.Frontiers in cardiovascular medicine · 2025Article
- Integrated SIRI and Lipid Profile for Early Prediction of Bloodstream Infection in AML During Induction Chemotherapy.Infection and drug resistance · 2025Article
- The Cardioprotective Effects of Nutritional Ketosis: Mechanisms and Clinical Implications.Nutrients · 2024Review
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6 authors.
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Abstract
Background: Coronary heart disease (CHD) is one of the common chronic diseases in clinical practice, often accompanied by inflammatory reactions. In recent years, the system inflammation response index (SIRI) has aroused researchers' interest as a novel inflammatory biomarker. This study aims to explore the relationship between the SIRI and CHD through the National Health and Nutrition Examination Survey (NHANES) database. Methods: We conducted a cross-sectional study and analyzed participants aged 40 and above with complete data from the NHANES survey years 2007-2016. Logistic regression analysis was used in this study to explore the relationship between the risk of CHD and SIRI. Stratified subgroup analysis was conducted based on age, gender, race, education level, body mass index (BMI), smoking status, drinking, hypertension, diabetes and angina pectoris to evaluate the relationship between SIRI and CHD in different populations. Additionally, restricted cubic spline (RCS) analysis was employed to investigate whether there is a nonlinear association between SIRI and CHD. Results: A total of 6374 eligible participants were included, among whom 387 were diagnosed with CHD. The SIRI levels in the CHD group were significantly higher than those in the non-CHD group. After adjusting for potential confounders, an elevated SIRI level was associated with an increased risk of CHD, with an odds ratio of 1.12, 95% CI: (1.03, 1.22), Conclusion: Our study indicates that an elevated system inflammation response index is associated with a higher risk of CHD. Particularly among women.
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