Evidence map›Paper›PMID 39188297›Full record

ReviewSmart medicine2023

Emerging biotechnologies and biomedical engineering technologies for hearing reconstruction.

Yangnan Hu, Le Fang, Hui Zhang, Shasha Zheng, Menghui Liao, Qingyue Cui, Hao Wei, Danqi Wu, Hong Cheng, Yanru Qi and 4 more

Abstract readReview
In one paragraph

Review in Smart medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Rational Design of Inner Ear Drug Delivery Systems.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  6. Multicargo Porous Cochlear Electrode Coating for Antifibrosis After Cochlear Implantation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yangnan HuState Key Laboratory of Digital Medical Engineering Department of Otolaryngology Head and Neck Surgery Zhongda Hospital School of Life Sciences and Technology Advanced Institute for Life and Health Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research Southeast University Nanjing China.
Le FangDepartment of Neurology The China-Japan Union Hospital of Jilin University Changchun Jilin China.
Hui ZhangState Key Laboratory of Digital Medical Engineering Department of Otolaryngology Head and Neck Surgery Zhongda Hospital School of Life Sciences and Technology Advanced Institute for Life and Health Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research Southeast University Nanjing China.ORCID https://orcid.org/0000-0001-5462-2479
Shasha ZhengState Key Laboratory of Digital Medical Engineering Department of Otolaryngology Head and Neck Surgery Zhongda Hospital School of Life Sciences and Technology Advanced Institute for Life and Health Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research Southeast University Nanjing China.
Menghui LiaoState Key Laboratory of Digital Medical Engineering Department of Otolaryngology Head and Neck Surgery Zhongda Hospital School of Life Sciences and Technology Advanced Institute for Life and Health Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research Southeast University Nanjing China.
Qingyue CuiState Key Laboratory of Digital Medical Engineering Department of Otolaryngology Head and Neck Surgery Zhongda Hospital School of Life Sciences and Technology Advanced Institute for Life and Health Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research Southeast University Nanjing China.
Hao WeiDepartment of Otolaryngology Head and Neck Surgery Affiliated Drum Tower Hospital of Nanjing University Medical School Jiangsu Provincial Key Medical Discipline Nanjing China.
Danqi WuState Key Laboratory of Digital Medical Engineering Department of Otolaryngology Head and Neck Surgery Zhongda Hospital School of Life Sciences and Technology Advanced Institute for Life and Health Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research Southeast University Nanjing China.
Hong ChengState Key Laboratory of Digital Medical Engineering Department of Otolaryngology Head and Neck Surgery Zhongda Hospital School of Life Sciences and Technology Advanced Institute for Life and Health Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research Southeast University Nanjing China.
Yanru QiState Key Laboratory of Digital Medical Engineering Department of Otolaryngology Head and Neck Surgery Zhongda Hospital School of Life Sciences and Technology Advanced Institute for Life and Health Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research Southeast University Nanjing China.
Huan WangThe Eighth Affiliated Hospital Sun Yat-Sen University Shenzhen China.ORCID https://orcid.org/0000-0001-5065-3702
Tao XinDepartment of Neurosurgery The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital Jinan China.
Tian WangDepartment of Otolaryngology-Head and Neck Surgery Stanford University School of Medicine Stanford California USA.
Renjie ChaiState Key Laboratory of Digital Medical Engineering Department of Otolaryngology Head and Neck Surgery Zhongda Hospital School of Life Sciences and Technology Advanced Institute for Life and Health Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research Southeast University Nanjing China.ORCID https://orcid.org/0000-0002-3885-543X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hearing impairment is a global health problem that affects social communications and the economy. The damage and loss of cochlear hair cells and spiral ganglion neurons (SGNs) as well as the degeneration of neurites of SGNs are the core causes of sensorineural hearing loss. Biotechnologies and biomedical engineering technologies provide new hope for the treatment of auditory diseases, which utilizes biological strategies or tissue engineering methods to achieve drug delivery and the regeneration of cells, tissues, and even organs. Here, the advancements in the applications of biotechnologies (including gene therapy and cochlear organoids) and biomedical engineering technologies (including drug delivery, electrode coating, electrical stimulation and bionic scaffolds) in the field of hearing reconstruction are presented. Moreover, we summarize the challenges and provide a perspective on this field.

Indexed as

drug deliveryelectrical stimulationgene therapyhearing reconstructionorganoid

Identifiers

PMID39188297
PMCPMC11235852

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.