Evidence map›Paper›PMID 39188278›Full record

ReviewSmart medicine2023

Piezoelectric biomaterials for neural tissue engineering.

Dongyu Xu, Hui Zhang, Yu Wang, Yuan Zhang, Fanglei Ye, Ling Lu, Renjie Chai

Abstract readReview
In one paragraph

Review in Smart medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. (Ba,Ca)(Ti,Sn)OFrontiers in cellular neuroscience · 2026
    Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dongyu XuState Key Laboratory of Bioelectronics Department of Otolaryngology Head and Neck Surgery Zhongda Hospital School of Life Sciences and Technology Advanced Institute for Life and Health Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research Southeast University Nanjing China.ORCID https://orcid.org/0000-0003-1740-4784
Hui ZhangState Key Laboratory of Bioelectronics Department of Otolaryngology Head and Neck Surgery Zhongda Hospital School of Life Sciences and Technology Advanced Institute for Life and Health Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research Southeast University Nanjing China.ORCID https://orcid.org/0000-0001-5462-2479
Yu WangState Key Laboratory of Bioelectronics Department of Otolaryngology Head and Neck Surgery Zhongda Hospital School of Life Sciences and Technology Advanced Institute for Life and Health Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research Southeast University Nanjing China.
Yuan ZhangDepartment of Otology The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan China.
Fanglei YeDepartment of Otology The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan China.
Ling LuDepartment of Otolaryngology Head and Neck Surgery Jiangsu Provincial Key Medical Discipline Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School Nanjing China.
Renjie ChaiState Key Laboratory of Bioelectronics Department of Otolaryngology Head and Neck Surgery Zhongda Hospital School of Life Sciences and Technology Advanced Institute for Life and Health Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research Southeast University Nanjing China.ORCID https://orcid.org/0000-0002-3885-543X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nerve injury caused by trauma or iatrogenic trauma can lead to loss of sensory and motor function, resulting in paralysis of patients. Inspired by endogenous bioelectricity and extracellular matrix, various external physical and chemical stimuli have been introduced to treat nerve injury. Benefiting from the self-power feature and great biocompatibility, piezoelectric biomaterials have attracted widespread attention in biomedical applications, especially in neural tissue engineering. Here, we provide an overview of the development of piezoelectric biomaterials for neural tissue engineering. First, several types of piezoelectric biomaterials are introduced, including inorganic piezoelectric nanomaterials, organic piezoelectric polymers, and their derivates. Then, we focus on the in vitro and in vivo external energy-driven piezoelectric effects involving ultrasound, mechanical movement, and other external field-driven piezoelectric effects. Neuroengineering applications of the piezoelectric biomaterials as in vivo grafts for the treatment of central nerve injury and peripheral nerve injury are also discussed and highlighted. Finally, the current challenges and future development of piezoelectric biomaterials for promoting nerve regeneration and treating neurological diseases are presented.

Indexed as

biomaterialsexternal energynerve regenerationpiezoelectricitywireless electrical stimulation

Identifiers

PMID39188278
PMCPMC11235970

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.