Evidence map›Paper›PMID 39188268›Full record

ArticleActa naturae

7-Methylguanine Inhibits Colon Cancer Growth in Vivo.

K I Kirsanov, T I Fetisov, E E Antoshina, T G Gor'kova, L S Trukhanova, S I Shram, I Yu Nagaev, Yu A Zolotarev, L Abo Qoura, V S Pokrovsky and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta naturae. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

K I KirsanovBlokhin National Medical Research Center of Oncology, Institute of Carcinogenesis, Moscow, 115478 Russian Federation.
T I FetisovBlokhin National Medical Research Center of Oncology, Institute of Carcinogenesis, Moscow, 115478 Russian Federation.
E E AntoshinaBlokhin National Medical Research Center of Oncology, Institute of Carcinogenesis, Moscow, 115478 Russian Federation.
T G Gor'kovaBlokhin National Medical Research Center of Oncology, Institute of Carcinogenesis, Moscow, 115478 Russian Federation.
L S TrukhanovaBlokhin National Medical Research Center of Oncology, Institute of Carcinogenesis, Moscow, 115478 Russian Federation.
S I ShramNational Research Centre "Kurchatov Institute", Moscow, 123182 Russian Federation.
I Yu NagaevNational Research Centre "Kurchatov Institute", Moscow, 123182 Russian Federation.
Yu A ZolotarevNational Research Centre "Kurchatov Institute", Moscow, 123182 Russian Federation.
L Abo QouraBlokhin National Medical Research Center of Oncology, Institute of Carcinogenesis, Moscow, 115478 Russian Federation.
V S PokrovskyBlokhin National Medical Research Center of Oncology, Institute of Carcinogenesis, Moscow, 115478 Russian Federation.
M G YakubovskayaBlokhin National Medical Research Center of Oncology, Institute of Carcinogenesis, Moscow, 115478 Russian Federation.
V K ŠvedasLomonosov Moscow State University, Belozersky Institute of Physicochemical Biology, Moscow, 119991 Russian Federation.
D K NilovLomonosov Moscow State University, Belozersky Institute of Physicochemical Biology, Moscow, 119991 Russian Federation.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

7-Methylguanine (7-MG) is a natural inhibitor of poly(ADP-ribose) polymerase 1 and tRNA-guanine transglycosylase, the enzymatic activity of which is central for the proliferation of cancer cells. Recently, a number of preclinical tests have demonstrated the safety of 7-MG and a regimen of intragastric administration was established in mice. In the present work, the pharmacological activity of 7-MG was studied in BALB/c and BALB/c nude mice with transplanted tumors. It was found that 7-MG effectively penetrates tumor tissue and suppresses colon adenocarcinoma growth in the Akatol model, as well as in a xenograft model with human HCT116 cells.

Indexed as

BALB/c micecolon cancerinhibitormethylguaninepoly(ADP-ribose) polymerase 1tRNA-guanine transglycosylase

Identifiers

PMID39188268
PMCPMC11345089

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.