ArticleJournal of neurodevelopmental disorders2024
Altered individual-level morphological similarity network in children with growth hormone deficiency.
Article in Journal of neurodevelopmental disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- The role of the subcortical structures in subthreshold depression: evidence from static and dynamic functional connectivity.Brain structure & function · 2026Article
- Gray matter volume and structural covariance alterations in young males with childhood-onset growth hormone deficiency.BMC medical imaging · 2026Article
- Morphological changes and lateralization of the thalamic nuclei in children with growth hormone deficiency.Frontiers in endocrinology · 2025Article
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12 authors.
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Abstract
backgroundAccumulating evidences indicate regional grey matter (GM) morphology alterations in pediatric growth hormone deficiency (GHD); however, large-scale morphological brain networks (MBNs) undergo these patients remains unclear.
objectiveTo investigate the topological organization of individual-level MBNs in pediatric GHD.
methodsSixty-one GHD and 42 typically developing controls (TDs) were enrolled. Inter-regional morphological similarity of GM was taken to construct individual-level MBNs. Between-group differences of topological parameters and network-based statistics analysis were compared. Finally, association relationship between network properties and clinical variables was analyzed.
resultsCompared to TDs, GHD indicated a disturbance in the normal small-world organization, reflected by increased L
conclusionGHD undergo an extensive reorganization in large-scale individual-level MBNs, probably due to abnormal cortico-striatal-thalamo-cerebellum loops, cortico-limbic-cerebellum, dorsal visual-sensorimotor-striatal, and auditory-cerebellum circuitry. This study highlights the crucial role of abnormal morphological connectivity underlying GHD, which might result in their relatively slower development in motor, cognitive, and linguistic functional within behavior problem performance.
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