Evidence map›Paper›PMID 39187767›Full record

ArticleBMC infectious diseases2024

Immunological insights: assessing immune parameters in medical professionals exposed to SARS-CoV-2.

Kamila Wojas-Krawczyk, Paweł Krawczyk, Justyna Błach, Tomasz Kucharczyk, Anna Grenda, Natalia Krzyżanowska, Katarzyna Szklener, Anna Horaczyńska-Wojtaś, Magdalena Wójcik-Superczyńska, Izabela Chmielewska and 1 more

Abstract read
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In one paragraph

Article in BMC infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kamila Wojas-KrawczykDepartment of Pneumonology, Oncology and Allergology Medical University of Lublin, Jaczewskiego 8, Lublin, 20-954, Poland. kamilawojas@wp.pl.
Paweł KrawczykDepartment of Pneumonology, Oncology and Allergology Medical University of Lublin, Jaczewskiego 8, Lublin, 20-954, Poland.
Justyna BłachDepartment of Pneumonology, Oncology and Allergology Medical University of Lublin, Jaczewskiego 8, Lublin, 20-954, Poland.
Tomasz KucharczykDepartment of Pneumonology, Oncology and Allergology Medical University of Lublin, Jaczewskiego 8, Lublin, 20-954, Poland.
Anna GrendaDepartment of Pneumonology, Oncology and Allergology Medical University of Lublin, Jaczewskiego 8, Lublin, 20-954, Poland.
Natalia KrzyżanowskaDepartment of Pneumonology, Oncology and Allergology Medical University of Lublin, Jaczewskiego 8, Lublin, 20-954, Poland.
Katarzyna SzklenerDepartment of Clinical Oncology and Chemotherapy Medical University of Lublin, Lublin, Poland.
Anna Horaczyńska-WojtaśDepartment of Pediatric Otolaryngology, Phoniatrics and Audiology, University Children's Hospital, Lublin, Poland.
Magdalena Wójcik-SuperczyńskaDepartment of Pneumonology, Oncology and Allergology Medical University of Lublin, Jaczewskiego 8, Lublin, 20-954, Poland.
Izabela ChmielewskaDepartment of Pneumonology, Oncology and Allergology Medical University of Lublin, Jaczewskiego 8, Lublin, 20-954, Poland.
Janusz MilanowskiDepartment of Pneumonology, Oncology and Allergology Medical University of Lublin, Jaczewskiego 8, Lublin, 20-954, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe immunological background responsible for the severe course of COVID-19 and the immune factors that protect against SARS-CoV-2 infection are still unclear. The aim of this study was to investigate immune system status in persons with high exposure to SARS-CoV-2 infection.

methodsSeventy-one persons employed in the observation and infectious diseases unit were qualified for the study between November 2020 and October 2021. Symptomatic COVID-19 was diagnosed in 35 persons. Anti-SARS-CoV-2 antibodies were also found in 8 persons. Peripheral blood mononuclear cells subpopulations were analyzed by flow cytometry, and the concentrations of cytokines and anti-SARS-CoV-2 antibodies were determined by ELISA.

resultsThe percentages of cytotoxic T lymphocytes (CTLs), CD28

conclusionNumerous lymphocyte populations are permanently altered by SARS-CoV-2 infection. High percentages of both populations: NK cells-as a part of the non-specific response, and T helper cells' as those regulating the immune response, could protect against the acute COVID-19 symptoms development. Understanding the immune background of COVID-19 may improve the prevention of this disease by identifying people at risk of a severe course of infection.

trial registrationThis is a retrospective observational study without a trial registration number.

Indexed as

Antibodies, ViralCOVID-19SARS-CoV-2AdultCytokinesFemaleHealth PersonnelHumansLeukocytes, MononuclearMaleMiddle AgedT-Lymphocytes, CytotoxicAntibodies, ViralCytokinesAnti-SARS-CoV-2 antibodiesCOVID-19Immunology systemPeripheral blood mononuclear cellsSARS-CoV-2 exposure

Identifiers

PMID39187767
PMCPMC11348584

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.