Evidence map›Paper›PMID 39187765›Full record

ArticleMolecular medicine (Cambridge, Mass.)2024

Secretome of brain microvascular endothelial cells promotes endothelial barrier tightness and protects against hypoxia-induced vascular leakage.

Rodrigo Azevedo Loiola, Johan Hachani, Sophie Duban-Deweer, Emmanuel Sevin, Paulina Bugno, Agnieszka Kowalska, Eleonora Rizzi, Fumitaka Shimizu, Takashi Kanda, Caroline Mysiorek and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine (Cambridge, Mass.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rodrigo Azevedo LoiolaUR 2465, Laboratory of the Blood-Brain Barrier (LBHE), Sciences Faculty Jean Perrin, Artois University, 62300, Lens, France.
Johan HachaniUR 2465, Laboratory of the Blood-Brain Barrier (LBHE), Sciences Faculty Jean Perrin, Artois University, 62300, Lens, France.
Sophie Duban-DeweerUR 2465, Laboratory of the Blood-Brain Barrier (LBHE), Sciences Faculty Jean Perrin, Artois University, 62300, Lens, France.
Emmanuel SevinUR 2465, Laboratory of the Blood-Brain Barrier (LBHE), Sciences Faculty Jean Perrin, Artois University, 62300, Lens, France.
Paulina BugnoPure Biologics S.A., Duńska 11, 54-427, Wroclaw, Poland.
Agnieszka KowalskaPure Biologics S.A., Duńska 11, 54-427, Wroclaw, Poland.
Eleonora RizziUR 2465, Laboratory of the Blood-Brain Barrier (LBHE), Sciences Faculty Jean Perrin, Artois University, 62300, Lens, France.
Fumitaka ShimizuDepartment of Neurology and Clinical Neuroscience, Graduate School of Medicine, Yamaguchi University, Ube, Japan.
Takashi KandaDepartment of Neurology and Clinical Neuroscience, Graduate School of Medicine, Yamaguchi University, Ube, Japan.
Caroline MysiorekUR 2465, Laboratory of the Blood-Brain Barrier (LBHE), Sciences Faculty Jean Perrin, Artois University, 62300, Lens, France.
Maciej MazurekPure Biologics S.A., Duńska 11, 54-427, Wroclaw, Poland.
Fabien GosseletUR 2465, Laboratory of the Blood-Brain Barrier (LBHE), Sciences Faculty Jean Perrin, Artois University, 62300, Lens, France. fabien.gosselet@univ-artois.fr.ORCID 0000-0002-0481-5026

Funding

Agence Nationale de la Recherche ANR-ANR-17-ENM3-0005-01H2020 Marie Skłodowska-Curie Actions 764958
6 · The paper itself

Abstract

Cell-based therapeutic strategies have been proposed as an alternative for brain and blood vessels repair after stroke, but their clinical application is hampered by potential adverse effects. We therefore tested the hypothesis that secretome of these cells might be used instead to still focus on cell-based therapeutic strategies. We therefore characterized the composition and the effect of the secretome of brain microvascular endothelial cells (BMECs) on primary in vitro human models of angiogenesis and vascular barrier. Two different secretome batches produced in high scale (scHSP) were analysed by mass spectrometry. Human primary CD34

Indexed as

Blood-Brain BarrierEndothelial CellsProteomicsBrainCapillary PermeabilityCell HypoxiaCells, CulturedHumansMicrovesselsProteomeSecretomeProteomeAngiogenesisBlood–brain barrierBrain microvascular endothelial cellsCardiovascular diseaseCell therapyRegenerative medicineSecretomeStroke

Identifiers

PMID39187765
PMCPMC11348522

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.