Evidence map›Paper›PMID 39187740›Full record

ArticleMolecular and cellular biochemistry2025

Antioxidative and cardioprotective effects of minocycline in ischemia/reperfusion injury in experimental model of hypertension.

Tamara Rudic, Aleksandra Stojanovic, Nikola Sobot, Jovana Novakovic, Sergey Bolevich, Stefani Bolevich, Vladimir Fisenko, Irina Nikolaevna Krylova, Marina Nikolic, Vladimir Jakovljevic and 1 more

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Article in Molecular and cellular biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Tamara RudicInpharm Co. d.O.O, Belgrade, Serbia.
Aleksandra StojanovicCenter of Excellence for the Study of Redox Balance in Cardiovascular and Metabolic Disorders, University of Kragujevac, Kragujevac, Serbia.
Nikola SobotClinic for Cardiac Surgery, University Clinical Centre of the Republic of Srpska, Banja Luka, Bosnia and Herzegovina.
Jovana NovakovicCenter of Excellence for the Study of Redox Balance in Cardiovascular and Metabolic Disorders, University of Kragujevac, Kragujevac, Serbia.
Sergey BolevichDepartment of Human Pathology, First Moscow State Medical University I.M. Sechenov, Moscow, Russia.
Stefani BolevichDepartment of Pathophysiology, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
Vladimir FisenkoDepartment of Pharmacology, First Moscow State, Medical University I.M. Sechenov, Moscow, Russia.
Irina Nikolaevna KrylovaDepartment of Pharmacology, First Moscow State, Medical University I.M. Sechenov, Moscow, Russia.
Marina NikolicCenter of Excellence for the Study of Redox Balance in Cardiovascular and Metabolic Disorders, University of Kragujevac, Kragujevac, Serbia.
Vladimir JakovljevicCenter of Excellence for the Study of Redox Balance in Cardiovascular and Metabolic Disorders, University of Kragujevac, Kragujevac, Serbia. drvladakgbg@yahoo.com.
Ivan SrejovicCenter of Excellence for the Study of Redox Balance in Cardiovascular and Metabolic Disorders, University of Kragujevac, Kragujevac, Serbia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular diseases remains leading cause of death and disabilities. Coronary artery occlusion and consequent ischemia leads to acute myocardial infarction, but restoration of blood flow, paradoxically, provokes further myocardial damage known as reperfusion injury. Minocycline is possessing anti-inflammatory and anti-apoptotic activity, immune-modulating and antioxidative properties besides its primary antibacterial effect. Recently it gained significant interest in preventing cardiac damage especially due to myocardial ischemia/reperfusion injury (MI/RI). The aim of this study was to assess the protective ability of pre-treatment and post-treatment of isolated hearts from healthy and spontaneously hypertensive rats with minocycline, on functional recovery and redox status after MI/RI using Langendorff technique. Using sensor in the left ventricle, the cardiodynamic parameters were recorded and in the samples of the coronary venous effluent oxidative stress biomarkers were analyzed. Minocycline was injected directly into the coronary vessels, in pre-treatment 5 min before global ischemia, and in post-treatment during the first 5 min of reperfusion. Changes in redox balance induced by minocycline were more prominent in post-treatment fashion of application. Cardioprotective effects of minocycline due to MI/RI are even more significant in hypertensive hearts. Minocycline showed significant cardioprotective effects, which was more pronounced in hypertensive compared to healthy hearts. Reduction of pro-oxidative biomarkers was more prominent in hypertensive hearts compared to the normotensive, especially if it is applied in the form of post-treatment. Minocycline could be important tool in reduction of heart damage induced by MI/RI due to its antioxidative potential, if these results are confirmed by clinical study.

Indexed as

AntioxidantsCardiotonic AgentsHypertensionMinocyclineMyocardial Reperfusion InjuryAnimalsDisease Models, AnimalMaleOxidative StressRatsRats, Inbred SHRAntioxidantsCardiotonic AgentsMinocyclineCardiodynamicIschemiaMinocyclineOxidative stressReperfusion

Identifiers

PMID39187740

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.