Evidence map›Paper›PMID 39187721›Full record

ArticleJournal of general internal medicine2024

Medications for Alcohol Use Disorder: Rates and Predictors of Prescription Order and Fill in Outpatient Settings.

Dominic Hodgkin, Alisa B Busch, Alene Kennedy-Hendricks, Hocine Azeni, Constance M Horgan, Lori Uscher-Pines, Haiden A Huskamp

Abstract read
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In one paragraph

Article in Journal of general internal medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Observational
  3. Article
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dominic HodgkinInstitute for Behavioral Health, Heller School for Social Policy and Management, Brandeis University, Waltham, MA, USA. hodgkin@brandeis.edu.ORCID 0000-0002-4494-9176
Alisa B BuschHarvard Medical School, Harvard University, Boston, MA, USA.
Alene Kennedy-HendricksJohns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Hocine AzeniHarvard Medical School, Harvard University, Boston, MA, USA.
Constance M HorganInstitute for Behavioral Health, Heller School for Social Policy and Management, Brandeis University, Waltham, MA, USA.
Lori Uscher-PinesRAND Corporation, Arlington, VA, USA.
Haiden A HuskampHarvard Medical School, Harvard University, Boston, MA, USA.

Funding

Research Support CoreP30DA035772 · NIDA · BRANDEIS UNIVERSITY · PI Maureen T Stewart · 2015 to 2026
$11.3M
Medications for Alcohol Use Disorder:  Unfilled Prescriptions and Treatment TrajectoriesR01AA029267 · NIAAA · HARVARD MEDICAL SCHOOL · PI HODGKIN, DOMINIC, HUSKAMP, HAIDEN A. · 2021 to 2024
$2.9M
NIAAA NIH HHS R01 AA029267NIDA NIH HHS P30 DA035772
6 · The paper itself

Abstract

backgroundAlcohol use disorders (AUD) are prevalent and responsible for substantial morbidity and mortality; yet efficacious treatments are underused. Previous studies have identified demographic and clinical predictors of medication fills, yet these studies typically do not include patients who were prescribed a medication but did not fill it.

objectivesTo examine rates of and factors associated with prescription order and prescription fill for medications for AUD (MAUD) among individuals diagnosed with AUD in outpatient settings.

designIn a cross-sectional analysis, we used multivariate logistic regression to identify factors associated with prescription order and fill. PATIENTS: We used data from the Optum Labs Data Warehouse that linked 2016-2021 de-identified claims and electronic health record (EHR) data, allowing us to observe prescription orders and whether they were filled. We identified 14,674 patients aged ≥ 18 who had an index outpatient encounter with an AUD diagnosis in the EHR. KEY MEASURES: We computed the proportion for whom a MAUD prescription was ordered within 1 year of index visit, and for whom one was filled within 30 days of the order. KEY

results5.8% of the sample had a MAUD prescription order within 1 year of their index visit. Among those with an order, 87% filled their MAUD prescription within 30 days of receipt (i.e., 5.1% of full sample). After multivariable adjustment, receipt of a MAUD prescription order was more likely for patients who were female (adjusted odds ratio (aOR) [95%CI] = 1.44 [1.24-1.67]), or had moderate or severe AUD (1.74 [1.50-2.01]). Patients receiving an order were more likely to fill it if they had a comorbid mental disorder (1.64 [1.09-2.49]).

conclusionsThe low rate of prescription orders was notable. Low use of MAUD appears to result chiefly from prescription order decisions, rather than from prescription fill decisions made by patients.

Indexed as

AlcoholismAdultAgedAlcohol DeterrentsAmbulatory CareCross-Sectional StudiesDrug MonitoringDrug PrescriptionsFemaleHumansMaleMiddle AgedOutpatientsYoung AdultAlcohol DeterrentsCascade of careConditional fill rateMedications for alcohol use disorderPrescription fillsPrescription orders

Identifiers

PMID39187721
PMCPMC11534947

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.