Evidence map›Paper›PMID 39187718›Full record

ArticleNature2024

Birth of protein folds and functions in the virome.

Jason Nomburg, Erin E Doherty, Nathan Price, Daniel Bellieny-Rabelo, Yong K Zhu, Jennifer A Doudna

Erratum issuedAbstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed.

  1. AnThe Journal of general virology · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. The diverse functions of viral microproteins.bioRxiv : the preprint server for biology · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Jason NomburgGladstone-UCSF Institute of Data Science and Biotechnology, San Francisco, CA, USA.ORCID 0000-0001-7807-8658
Erin E DohertyInnovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0002-1555-4124
Nathan PriceGladstone-UCSF Institute of Data Science and Biotechnology, San Francisco, CA, USA.ORCID 0000-0002-7008-4620
Daniel Bellieny-RabeloInnovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0003-2544-7899
Yong K ZhuGladstone-UCSF Institute of Data Science and Biotechnology, San Francisco, CA, USA.
Jennifer A DoudnaGladstone-UCSF Institute of Data Science and Biotechnology, San Francisco, CA, USA. doudna@berkeley.edu.ORCID 0000-0001-9161-999X

Funding

Targeting Viroporins and Coronavirus M ProteinU19AI171110 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Nevan J Krogan · 2022 to 2026
$103.4M
Project 3U54AI170792 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Nevan J Krogan · 2022 to 2026
$35.7M
RESEARCH PROJECT 2U19AI135990 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Danielle L Swaney · 2018 to 2026
$21.4M
Resource Core II: In Vivo CoreU19NS132303 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI NIREN MURTHY · 2023 to 2026
$19.7M
Expanding CRISPR-Cas editing technology through exploration of novel Cas proteins and DNA repair systemsU01AI142817 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI BANFIELD, JILLIAN, DOUDNA, JENNIFER A · 2018 to 2022
$2.0M
Cas9 RNP delivery to immune cells in vivo via molecular targetingUH3AI150552 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI DOUDNA, JENNIFER A, WILSON, ROSS C · 2022 to 2022
$1.3M
Targeted Delivery of Cas9 to Lung Epithelial Cells using Enveloped Delivery VehiclesR21HL173710 · NHLBI · J. DAVID GLADSTONE INSTITUTES · PI DOUDNA, JENNIFER A · 2024 to 2025
$520k
Precision Deaminases to Expand the Scope of Diseases Amenable to CRISPR-mediated CorrectionF32GM153031 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Erin E Doherty · 2024 to 2026
$229k
NHLBI NIH HHS R21 HL173710NIAID NIH HHS U01 AI142817NIAID NIH HHS U19 AI135990NIAID NIH HHS U54 AI170792NIAID NIH HHS UH3 AI150552NIGMS NIH HHS F32 GM153031NINDS NIH HHS U19 NS132303
6 · The paper itself

Abstract

The rapid evolution of viruses generates proteins that are essential for infectivity and replication but with unknown functions, due to extreme sequence divergence

Indexed as

Protein FoldingViral ProteinsViromeAnimalsBacteriophagesDatabases, ProteinHost Microbial InteractionsHumansHydrolysisImmune EvasionImmunity, InnateModels, MolecularNucleotides, CyclicPhosphoric Diester Hydrolasescyclic guanosine monophosphate-adenosine monophosphateNucleotides, CyclicPhosphoric Diester HydrolasesViral Proteins

Identifiers

PMID39187718
PMCPMC11410667

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.