ArticleNature communications2024
Harnessing forward multiple scattering for optical imaging deep inside an opaque medium.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The trial behind it
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Who cites it
8 citing papers in PubMed.
- Multiplexed optoacoustic tracking and magnetic actuation of labeled blood cells in living mice.Science advances · 2026Article
- Rapid wavefront shaping using an optical gradient acquisition.Nature communications · 2026Article
- Article
- Quantum-inspired computational wavefront shaping enables turbulence-resilient distributed aperture synthesis imaging.Science advances · 2025Article
- Isolating subsurface fluorescence in macroscopic lifetime imaging via high-spatial-frequency structured illumination.JPhys photonics · 2025Article
- Matrix-based imaging through dynamic scattering.Nature communications · 2025Article
- Noninvasive megapixel fluorescence microscopy through scattering layers by a virtual incoherent reflection matrix.Science advances · 2024Article
- Matrix imaging as a tool for high-resolution monitoring of deep volcanic plumbing systems with seismic noise.Communications earth & environment · 2024Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
As light travels through a disordered medium such as biological tissues, it undergoes multiple scattering events. This phenomenon is detrimental to in-depth optical microscopy, as it causes a drastic degradation of contrast, resolution and brightness of the resulting image beyond a few scattering mean free paths. However, the information about the inner reflectivity of the sample is not lost; only scrambled. To recover this information, a matrix approach of optical imaging can be fruitful. Here, we report on a de-scanned measurement of a high-dimension reflection matrix R via low coherence interferometry. Then, we show how a set of independent focusing laws can be extracted for each medium voxel through an iterative multi-scale analysis of wave distortions contained in R. It enables an optimal and local compensation of forward multiple scattering paths and provides a three-dimensional confocal image of the sample as the latter one had become digitally transparent. The proof-of-concept experiment is performed on a human opaque cornea and an extension of the penetration depth by a factor five is demonstrated compared to the state-of-the-art.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.