Evidence map›Paper›PMID 39187389›Full record

ArticleMolecular pharmacology2024

Ghrelin Modulates Voltage-Gated Ca

Hannah J Goudsward, Victor Ruiz-Velasco, Salvatore L Stella, Paul B Herold, Gregory M Holmes

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Role of voltage-gated CaJournal of neurophysiology · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hannah J GoudswardDepartments of Neural and Behavioral Sciences (H.J.G., S.L.S., G.M.H.) and Anesthesiology and Perioperative Medicine (V.R.-V., P.B.H.), Penn State University College of Medicine, Hershey, Pennsylvania.
Victor Ruiz-VelascoDepartments of Neural and Behavioral Sciences (H.J.G., S.L.S., G.M.H.) and Anesthesiology and Perioperative Medicine (V.R.-V., P.B.H.), Penn State University College of Medicine, Hershey, Pennsylvania.
Salvatore L StellaDepartments of Neural and Behavioral Sciences (H.J.G., S.L.S., G.M.H.) and Anesthesiology and Perioperative Medicine (V.R.-V., P.B.H.), Penn State University College of Medicine, Hershey, Pennsylvania.
Paul B HeroldDepartments of Neural and Behavioral Sciences (H.J.G., S.L.S., G.M.H.) and Anesthesiology and Perioperative Medicine (V.R.-V., P.B.H.), Penn State University College of Medicine, Hershey, Pennsylvania.
Gregory M HolmesDepartments of Neural and Behavioral Sciences (H.J.G., S.L.S., G.M.H.) and Anesthesiology and Perioperative Medicine (V.R.-V., P.B.H.), Penn State University College of Medicine, Hershey, Pennsylvania gmh16@psu.edu.ORCID 0000-0001-5176-8376

Funding

Pathophysiological remodeling of the enteric neuromuscular compartment in experimental spinal cord injuryR01NS105987 · NINDS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI HOLMES, GREGORY M. · 2019 to 2023
$1.7M
Ghrelin Modulation of CaV 2.2 Channels After Spinal Cord InjuryF31DK136279 · NIDDK · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI GOUDSWARD, HANNAH J · 2023 to 2024
$70k
NIDDK NIH HHS F31 DK136279NINDS NIH HHS R01 NS105987
6 · The paper itself

Abstract

The orexigenic gut peptide ghrelin is an endogenous ligand for the growth hormone secretagogue receptor type 1a (GHSR1a). Systemic ghrelin administration has previously been shown to increase gastric motility and emptying. While these effects are known to be mediated by the vagus nerve, the cellular mechanism underlying these effects remains unclear. Therefore, the purpose of the present study was to investigate the signaling mechanism by which GHSR1a inhibits voltage-gated Ca

Indexed as

Calcium ChannelsGhrelinNeurons, AfferentReceptors, GhrelinVagus NerveAnimalsMaleOligopeptidesPatch-Clamp TechniquesRatsRats, WistarSignal TransductionStomachCalcium ChannelsGhrelinGHRP-6, Lys(3)-Ghsr1a protein, ratOligopeptidesReceptors, Ghrelin

Identifiers

PMID39187389
PMCPMC11493335

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.