Evidence map›Paper›PMID 39187377›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2024

Distinct Neuromodulatory Effects of Endogenous Orexin and Dynorphin Corelease on Projection-Defined Ventral Tegmental Dopamine Neurons.

Aida Mohammadkhani, Min Qiao, Stephanie L Borgland

Abstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Tug-of-War: Orexin and Dynorphin Effects on Reward Processing Circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Aida MohammadkhaniDepartment of Physiology and Pharmacology, Hotchkiss Brain Institute, The University of Calgary, Calgary, AB T2N 4N1, Canada.ORCID 0000-0003-2267-6266
Min QiaoDepartment of Physiology and Pharmacology, Hotchkiss Brain Institute, The University of Calgary, Calgary, AB T2N 4N1, Canada.
Stephanie L BorglandDepartment of Physiology and Pharmacology, Hotchkiss Brain Institute, The University of Calgary, Calgary, AB T2N 4N1, Canada s.borgland@ucalgary.ca.ORCID 0000-0001-7546-5687

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dopamine (DA) neurons in the ventral tegmental area (VTA) respond to motivationally relevant cues, and circuit-specific signaling drives different aspects of motivated behavior. Orexin (ox; also known as hypocretin) and dynorphin (dyn) are coexpressed lateral hypothalamic (LH) neuropeptides that project to the VTA. These peptides have opposing effects on the firing activity of VTA

Indexed as

Dopaminergic NeuronsDynorphinsOrexinsVentral Tegmental AreaAnimalsFemaleHypothalamic Area, LateralMaleMiceMice, Inbred C57BLMice, TransgenicNeural PathwaysNucleus AccumbensOptogeneticsOrexin ReceptorsDynorphinsOrexin ReceptorsOrexinsdopaminedynorphinneuropeptideorexinventral tegmental area

Identifiers

PMID39187377
PMCPMC11426376

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.