Evidence map›Paper›PMID 39187374›Full record

ArticleLife science alliance2024

mTORC1 hampers Hedgehog signaling in

Lasse Jonsgaard Larsen, Elsebet Østergaard, Lisbeth Birk Møller

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. TSC2 is a stress granule suppressor.bioRxiv : the preprint server for biology · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lasse Jonsgaard LarsenDepartment of Genetics, Kennedy Center, Copenhagen University Hospital, Rigshospitalet, Glostrup, Denmark.
Elsebet ØstergaardDepartment of Genetics, Kennedy Center, Copenhagen University Hospital, Rigshospitalet, Glostrup, Denmark.
Lisbeth Birk MøllerDepartment of Genetics, Kennedy Center, Copenhagen University Hospital, Rigshospitalet, Glostrup, Denmark Lisbeth.Birk.Moeller@Regionh.dk.ORCID 0000-0002-9524-4301

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mTORC1-complex is negatively regulated by TSC1 and TSC2. Activation of Hedgehog signaling is strictly dependent on communication between Smoothened and the Hedgehog-signaling effector and transcription factor, GLI2, in the primary cilium. Details about this communication are not known, and we wanted to explore this further. Here we report that in

Indexed as

Hedgehog ProteinsMechanistic Target of Rapamycin Complex 1Signal TransductionSmoothened ReceptorTuberous Sclerosis Complex 2 ProteinTumor Suppressor ProteinsZinc Finger Protein Gli2AnimalsCell MembraneCiliaFibroblastsKruppel-Like Transcription FactorsMiceMice, KnockoutZinc Finger Protein GLI1Gli1 protein, mouseGli2 protein, mouseHedgehog ProteinsKruppel-Like Transcription FactorsMechanistic Target of Rapamycin Complex 1Smoothened ReceptorSmo protein, mouseTsc2 protein, mouseTuberous Sclerosis Complex 2 ProteinTumor Suppressor ProteinsZinc Finger Protein GLI1Zinc Finger Protein Gli2

Identifiers

PMID39187374
PMCPMC11349048

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.