Evidence map›Paper›PMID 39187368›Full record

ArticleIn vivo (Athens, Greece)

Analysis of Single Nucleotide Polymorphisms (SNPs) rs2234693 and rs9340799 of the

Beata Smolarz, Anna Zadrożna Nowak, Magdalena Bryś, Ewa Forma, Honorata Łukasiewicz, Dariusz Samulak, Sara Langner, Hanna Romanowicz

Abstract read
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In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Study of Estrogen Receptor Alpha Gene Polymorphisms (International journal of molecular sciences · 2026
    Article
  4. Human mutation · 2026
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Beata SmolarzLaboratory of Cancer Genetics, Department of Pathology, Polish Mother's Memorial Hospital Research Institute, Lodz, Poland; smolbea@wp.pl.
Anna Zadrożna NowakDepartment of Chemotherapy, Medical University of Lodz, Copernicus Memorial Hospital, Lodz, Poland.
Magdalena BryśDepartment of Cytobiochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland.
Ewa FormaDepartment of Cytobiochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland.
Honorata ŁukasiewiczDepartment of Obstetrics and Gynecology and Gynecological Oncology, Regional Hospital in Kalisz, Kalisz, Poland.
Dariusz SamulakDepartment of Obstetrics and Gynecology and Gynecological Oncology, Regional Hospital in Kalisz, Kalisz, Poland.
Sara LangnerMedical University of Gdańsk, Gdańsk, Poland.
Hanna RomanowiczLaboratory of Cancer Genetics, Department of Pathology, Polish Mother's Memorial Hospital Research Institute, Lodz, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimThe aim of this study was to analyze rs2234693 and rs9340799 polymorphisms of the ESR1 gene in the context of breast cancer risk in Polish patients. MATERIALS AND

methodsThe study involved a group of 117 patients with breast cancer and 106 controls. The analyses were carried out using the polymerase chain reaction - restriction fragments length polymorphism technique.

resultsThe presence of the CC genotype in rs2234693 more than doubled the risk of breast cancer (p=0.04), whereas the presence of the TT genotype in rs2234693 significantly reduced the risk of developing this type of cancer (p=0.0002). The presence of the GG genotype in rs9340799 more than doubled the risk of breast cancer (p=0.04), which was confirmed by the analysis of the recessive model (p=0.04).

conclusionThe polymorphisms rs2234693 and rs9340799 of the ESR1 gene may be associated with the risk of breast cancer among Polish women.

Indexed as

Breast NeoplasmsEstrogen Receptor alphaGenetic Predisposition to DiseaseGenotypePolymorphism, Single NucleotideAdultAgedAllelesCase-Control StudiesFemaleGene FrequencyGenetic Association StudiesHumansMiddle AgedPolandRisk FactorsESR1 protein, humanEstrogen Receptor alphabreast cancerESR1polymorphismrs2234693rs9340799

Identifiers

PMID39187368
PMCPMC11363788

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.