ArticleIn vivo (Athens, Greece)
Distribution Patterns of Benign and Malignant Bone and Soft Tissue Tumors and Tumor-like lesions in the Hindfoot and Ankle: A 12.5-year Analysis.
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Who cites it
2 citing papers in PubMed.
- A Soft Tissue Osteochondrolipoma of the Lateral Ankle: A Case Report and Clinical Insight.Case reports in orthopedics · 2026Article
- Retrospective clinicopathological analysis of 193 cases of bone and soft tissue tumors in the foot and ankle.Acta orthopaedica et traumatologica turcica · 2025Article
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7 authors.
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Abstract
BACKGROUND/
aimBenign and tumor-like lesions of the hindfoot and ankle are common, whereas malignant entities are rare. Accurate evaluation and timely management of these lesions can be challenging, making it crucial to understand their incidence and anatomic localization. This study retrospectively analyzed the distribution of benign and malignant bone and soft tissue tumors in the hindfoot and ankle. PATIENTS AND
methodsThis study included patient data from a single center, such as age, sex, histologic diagnosis, and anatomic location over a 12.5 year period.
resultsOf the 105 cases reviewed, 19 cases (18.1%) were osseous lesions and 86 cases (81.9%) were soft tissue lesions. The latter were divided into 77 benign and 9 malignant cases, resulting in an overall malignancy rate of 8.6%. The most common osseous lesion was the intraosseous ganglion (n=12). The majority of benign soft tissue lesions (75.3%) were located in the hindfoot, with TGCT, schwannoma, and ganglion cysts being the most common types. The nine malignant cases were distributed among seven entities and were evenly distributed among both regions and sexes. Malignant cases had a higher mean age (59.2 years) compared to benign cases (40.8 years; p=0.001).
conclusionTumors, tumor-like lesions, and pseudotumors represent an important aspect of ankle pathology. The majority of focal masses and swellings are benign soft tissue or osseous lesions, but malignant entities can occur and may be mistaken for benign conditions. Preoperative imaging and histopathologic examination are essential, and preoperative presentation to a multidisciplinary tumor board is recommended in unclear cases.
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