Evidence map›Paper›PMID 39187322›Full record

ArticleIn vivo (Athens, Greece)

Lack of RAMP1 Signaling Suppresses Liver Regeneration and Angiogenesis Following Partial Hepatectomy in Mice.

Shuji Nakamoto, Yoshiya Ito, Nobuyuki Nishizawa, Y U Kuroda, Kanako Hosono, Mariko Kamata, Kazutake Tsujikawa, Yusuke Kumamoto, Hideki Amano

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shuji NakamotoDepartment of General-Pediatric-Hepatobiliary Pancreatic Surgery, Kitasato University School of Medicine, Sagamihara, Japan.
Yoshiya ItoDepartment of Pharmacology, Kitasato University School of Medicine, Sagamihara, Japan; yito@kitasato-u.ac.jp.
Nobuyuki NishizawaDepartment of General-Pediatric-Hepatobiliary Pancreatic Surgery, Kitasato University School of Medicine, Sagamihara, Japan.
Y U KurodaDepartment of Molecular Pharmacology, Graduate School of Medical Sciences, Kitasato University, Sagamihara, Japan.
Kanako HosonoDepartment of Pharmacology, Kitasato University School of Medicine, Sagamihara, Japan.
Mariko KamataDepartment of Pharmacology, Kitasato University School of Medicine, Sagamihara, Japan.
Kazutake TsujikawaLaboratory of Molecular and Cellular Physiology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan.
Yusuke KumamotoDepartment of General-Pediatric-Hepatobiliary Pancreatic Surgery, Kitasato University School of Medicine, Sagamihara, Japan.
Hideki AmanoDepartment of Pharmacology, Kitasato University School of Medicine, Sagamihara, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimThe liver effectively restores both size and function following partial hepatectomy (PHx). Angiogenesis is crucial for the repair and regeneration of liver tissue post-PHx. Calcitonin gene-related peptide (CGRP) released from sensory nerves and its receptor-receptor activity-modifying protein 1 (RAMP1) are involved in angiogenesis. This study aimed to assess the role of RAMP1 signaling in angiogenesis during liver regeneration following PHx. MATERIALS AND

methodsRAMP1 deficient (RAMP1

resultsRAMP1

conclusionThe deletion of RAMP1 signaling suppresses liver regeneration and angiogenesis through VEGFR3. Specific activation of RAMP1 signaling may represent a potential therapeutic strategy for liver regeneration following PHx.

Indexed as

HepatectomyLiver RegenerationMice, KnockoutNeovascularization, PhysiologicReceptor Activity-Modifying Protein 1Signal TransductionAngiogenesisAnimalsHepatocytesLiverMaleMiceRamp1 protein, mouseReceptor Activity-Modifying Protein 1angiogenesisLiver regenerationRAMP1

Identifiers

PMID39187322
PMCPMC11363762

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.