Evidence map›Paper›PMID 39187321›Full record

ArticleIn vivo (Athens, Greece)

Investigation of Ionization Chamber Characteristics for Ultrahigh-dose-rate Scanned Carbon-ion Beams.

Noriaki Hamatani, Masashi Yagi, Shinichi Shimizu, Naoki Ishino, Masaki Shimizu, Yoshiaki Kuwana, Toshiro Tsubouchi, Masaaki Takashina, Takuto Miyoshi, Takuya Nomura and 6 more

Abstract read
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Noriaki HamataniDepartment of Medical Physics, Osaka Heavy-Ion Therapy Center, Osaka, Japan; n.hamatani@osaka-himak.or.jp.
Masashi YagiDepartment of Carbon-Ion Radiotherapy, Graduate School of Medicine, Osaka University, Osaka, Japan; m.yagi@radonc.med.osaka-u.ac.jp.
Shinichi ShimizuDepartment of Carbon-Ion Radiotherapy, Graduate School of Medicine, Osaka University, Osaka, Japan.
Naoki IshinoMedical Physics for Particle Therapy Laboratory, Department of Biophysical Engineering, Division of Health Sciences, Osaka University Graduate School of Medicine, Osaka, Japan.
Masaki ShimizuHealthcare Business Groupe, Hitachi High-Tech Corporation, Chiba, Japan.
Yoshiaki KuwanaHealthcare Business Groupe, Hitachi High-Tech Corporation, Chiba, Japan.
Toshiro TsubouchiDepartment of Medical Physics, Osaka Heavy-Ion Therapy Center, Osaka, Japan.
Masaaki TakashinaDepartment of Medical Physics, Osaka Heavy-Ion Therapy Center, Osaka, Japan.
Takuto MiyoshiHealthcare Business Groupe, Hitachi High-Tech Corporation, Chiba, Japan.
Takuya NomuraHealthcare Business Groupe, Hitachi High-Tech Corporation, Chiba, Japan.
Takashi ToyodaHealthcare Business Groupe, Hitachi High-Tech Corporation, Chiba, Japan.
Masumi UmezawaHealthcare Business Groupe, Hitachi High-Tech Corporation, Chiba, Japan.
Teiji NishioMedical Physics Laboratory, Department of Biophysical Engineering, Division of Health Sciences, Osaka University Graduate School of Medicine, Osaka, Japan.
Masahiko KoizumiRadiation Oncology Laboratory, Department of Biophysical Engineering, Division of Health Sciences, Osaka University Graduate School of Medicine, Osaka, Japan.
Kazuhiko OgawaDepartment of Radiation Oncology, Osaka University Graduate School of Medicine, Osaka, Japan.
Tatsuaki KanaiMedical Physics for Particle Therapy Laboratory, Department of Biophysical Engineering, Division of Health Sciences, Osaka University Graduate School of Medicine, Osaka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimThere are only a few studies on dosimetry with ultrahigh-dose-rate (uHDR) scanned carbon-ion beams. This study investigated the characteristics of four types of ionization chambers for the uHDR beam. MATERIALS AND

methodsWe employed a newly developed large-plane parallel chamber to monitor a 208.3-MeV/u uHDR scanned carbon-ion beam with a 110-Gy/s average dose rate. The ionization chambers used were the Advanced Markus chamber (AMC), PinPoint 3D chamber (PPC), Farmer chamber (FC), and large-plane parallel chamber (StingRay). The AMC and StingRay surfaces and the PPC and FC geometric centers were aligned to the radiation isocenter using treatment room lasers. Using the voltage range stated in the instruction manuals, we obtained the saturation curves of the chambers. From these curves, we obtained the ion recombination correction factors using the two-voltage and three-voltage linear methods. The dose linearity was evaluated using five measurement points, and the chamber repeatability was verified by conducting repeated measurements for different dose values.

resultsAlthough all chambers, except for AMC, reached saturation when specified voltages were applied, they exhibited excellent linearity for different dose values. The ion recombination correction factors of the AMC obtained using the aforementioned linear methods were nearly 1. Additionally, all chambers exhibited excellent repeatability. Although the standard deviation of the PPC for the lowest dose was ~1.5%, those of all the other chambers were <1.0%.

conclusionAll ionization chambers can be used for measuring the relative dose, and absolute dose can be conveniently measured using the AMC with an uHDR carbon-ion scanned beam.

Indexed as

Heavy Ion RadiotherapyRadiometryRadiotherapy DosageCarbonHumansCarbonionization chamberscanned carbon-ion beamUltrahigh dose rate (uHDR; FLASH)

Identifiers

PMID39187321
PMCPMC11363756

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.