Evidence map›Paper›PMID 39187036›Full record

ArticlePhysiology & behavior2024

Prevention and reversal of neuropathic pain by near-infrared photobiomodulation therapy in male and female rats.

Marucia Chacur, Igor R Correia Rocha, Michael E Harland, Suzanne M Green-Fulgham, Sonia Regina Yokomizo de Almeida, Adriano Polican Ciena, Linda R Watkins

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Article in Physiology & behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marucia ChacurDepartment of Psychology and Neuroscience, and the Center for Neuroscience, University of Colorado, Boulder, CO 80309, USA; Laboratory of Neuroanatomy Functional of Pain, Departamento de Anatomia, Institute of Biomedical Science, Universidade de Sao Paulo, 05508-900 Sao Paulo, Brazil. Electronic address: chacurm@icb.usp.br.
Igor R Correia RochaDepartment of Psychology and Neuroscience, and the Center for Neuroscience, University of Colorado, Boulder, CO 80309, USA; Laboratory of Neuroanatomy Functional of Pain, Departamento de Anatomia, Institute of Biomedical Science, Universidade de Sao Paulo, 05508-900 Sao Paulo, Brazil.
Michael E HarlandDepartment of Psychology and Neuroscience, and the Center for Neuroscience, University of Colorado, Boulder, CO 80309, USA.
Suzanne M Green-FulghamDepartment of Psychology and Neuroscience, and the Center for Neuroscience, University of Colorado, Boulder, CO 80309, USA.
Sonia Regina Yokomizo de AlmeidaLaboratory of Neuroanatomy Functional of Pain, Departamento de Anatomia, Institute of Biomedical Science, Universidade de Sao Paulo, 05508-900 Sao Paulo, Brazil.
Adriano Polican CienaLaboratory of Morphology and Physical Activity (LAMAF), Institute of Biosciences, Sao Paulo State University (UNESP), Rio Claro 13506-900 Sao Paulo, Brazil.
Linda R WatkinsDepartment of Psychology and Neuroscience, and the Center for Neuroscience, University of Colorado, Boulder, CO 80309, USA.

Funding

Enduring enhancement of neuropathic pain by early post-trauma morphineR01DA044934 · NIDA · UNIVERSITY OF COLORADO · PI WATKINS, LINDA · 2018 to 2022
$2.7M
Targeting neuropathic pain prevention: Modulating the neuroimmunology of peripheral nerve injuryR01AT009366 · NCCIH · UNIVERSITY OF COLORADO · PI WATKINS, LINDA · 2017 to 2021
$1.7M
NCCIH NIH HHS R01 AT009366NIDA NIH HHS R01 DA044934
6 · The paper itself

Abstract

Pathological nociception arising from peripheral nerve injury impacts quality of life. Current therapeutics are generally ineffective. However, photobiomodulation therapy (PBMT) has shown promise in addressing this issue. We aimed to assess the potential anti-allodynic effects of 2 p.m. protocols, each applied transcutaneously over the peripheral nerve injury. In addition to evaluating nociceptive behavior, we also conducted morphological analysis using electron microscopy (EM) to investigate potential ultrastructural changes at the cellular level. We sought to determine, using the chronic constriction injury (CCI) model, whether our parameters could alleviate established allodynia and/or dampen allodynia development. Adult male and female rats with CCI or sham were treated with PBMT (850-nm wavelength) for 2 min, 3 times a week over three or four weeks across three studies, where PBMT began either before or after CCI. Allodynia was assessed prior to surgery and across weeks and, at the conclusion of the third study, sciatic nerve was processed for EM and histomorphometrically evaluated. The results showed that PBMT before versus after CCI injury yielded similar behaviors, effectively decreasing allodynia. Interestingly, these positive effects of PBMT do not appear to be accounted by protection of the sciatic injury site, based on EM. CCI reliably decreased axon size and the number of myelinated axons present in both PBMT and control groups. While PBMT reduced the number of C-fibers in CCI samples, no improvement in any measure was observed in response to PBMT.

Indexed as

HyperalgesiaLow-Level Light TherapyNeuralgiaRats, Sprague-DawleyAnimalsDisease Models, AnimalFemaleInfrared RaysMalePain MeasurementRatsSciatic NerveAllodyniaChronic constriction injuryElectron microscopyHistomorphometric analysisSciatic nerve

Identifiers

PMID39187036
PMCPMC11425085

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.