Evidence map›Paper›PMID 39186971›Full record

ArticleContemporary clinical trials2024

Behavioral activation for veterans with co-occurring alcohol use disorder and posttraumatic stress disorder: Basis and methodology for a pilot randomized controlled trial.

Shannon M Blakey, Amber K Alsobrooks, Antonio A Morgan-López, Nicholas Kruskamp, Tracy L Simpson, Stacey B Daughters, Chase M DuBois, Jovin S Huang, Janequia Evans, Bethzaida N Serrano and 3 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary clinical trials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06249386 (Adapting and Piloting Behavioral Activation for Veterans With Co-Occurring AUD and Posttraumatic Stress Disorder), which is not on this map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06249386 nacompletednot on this mapstarted 2025, after this paper: background citation

Adapting and Piloting Behavioral Activation for Veterans With Co-Occurring AUD and Posttraumatic Stress Disorder

TypeinterventionalSponsorRTI InternationalRan2025 to 2025Enrolled10ConditionsAlcohol Use Disorder, Posttraumatic Stress DisorderArmsBehavioral Activation (BA), Relapse Prevention (RP)
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Shannon M BlakeyRTI International, 3040 E. Cornwallis Rd, P.O. Box 12194, Research Triangle Park, NC 27709-2194, USA. Electronic address: sblakey@rti.org.
Amber K AlsobrooksDuke University School of Medicine, Duke North Pavilion, 2400 Pratt Street, Durham, NC 27705, USA.
Antonio A Morgan-LópezRTI International, 3040 E. Cornwallis Rd, P.O. Box 12194, Research Triangle Park, NC 27709-2194, USA.
Nicholas KruskampRTI International, 3040 E. Cornwallis Rd, P.O. Box 12194, Research Triangle Park, NC 27709-2194, USA.
Tracy L SimpsonUniversity of Washington School of Medicine, 1959 NE Pacific Street, Seattle, WA 98195, USA; VA Puget Sound Health Care System, 1660 S. Columbian Way, Seattle, WA 98108, USA; Center of Excellence in Substance Addiction Treatment & Education, 1660 S. Columbian Way, Seattle, WA 98108, USA.
Stacey B DaughtersUniversity of North Carolina at Chapel Hill, Department of Psychology and Neuroscience, CB 3270, Chapel Hill, NC 27599-3270, USA.
Chase M DuBoisDuke University School of Medicine, Duke North Pavilion, 2400 Pratt Street, Durham, NC 27705, USA.
Jovin S HuangDuke University School of Medicine, Duke North Pavilion, 2400 Pratt Street, Durham, NC 27705, USA.
Janequia EvansDuke University School of Medicine, Duke North Pavilion, 2400 Pratt Street, Durham, NC 27705, USA.
Bethzaida N SerranoDuke University School of Medicine, Duke North Pavilion, 2400 Pratt Street, Durham, NC 27705, USA.
Patrick S CalhounDuke University School of Medicine, Duke North Pavilion, 2400 Pratt Street, Durham, NC 27705, USA; Durham VA Health Care System, 508 Fulton Street, Durham, NC 27705, United States of America.
Jean C BeckhamDuke University School of Medicine, Duke North Pavilion, 2400 Pratt Street, Durham, NC 27705, USA; Durham VA Health Care System, 508 Fulton Street, Durham, NC 27705, United States of America.
Eric B ElbogenDuke University School of Medicine, Duke North Pavilion, 2400 Pratt Street, Durham, NC 27705, USA.

Funding

Adapting and Piloting Behavioral Activation for Veterans with Co-Occurring AUD and Posttraumatic Stress DisorderR34AA030820 · NIAAA · RESEARCH TRIANGLE INSTITUTE · PI BLAKEY, SHANNON MICHELLE, ELBOGEN, ERIC B. · 2023 to 2025
$748k
CSR&D Research Career Scientist AwardIK6BX003777 · VA · DURHAM VA MEDICAL CENTER · PI BECKHAM, JEAN C. · 2017 to 2023
–
BLRD VA IK6 BX003777CSRD VA IK6 CX002767NIAAA NIH HHS R34 AA030820
6 · The paper itself

Abstract

backgroundNearly 2 million U.S. veterans live with co-occurring alcohol use disorder and posttraumatic stress disorder (AUD/PTSD). Extant AUD/PTSD treatments emphasize symptom reduction, sometimes overlooking psychosocial functioning improvements, and have dropout rates as high as 50 %. Additionally, current approaches to measuring psychosocial functioning are limited to self-report. This study protocol describes a 1:1 parallel, two-arm, pilot randomized controlled trial comparing Behavioral Activation (BA) psychotherapy to Relapse Prevention (RP) psychotherapy for veterans with AUD/PTSD.

methodsForty-six veterans with AUD/PTSD will be block-randomized to eight weekly, virtual, hour-long individual sessions of BA or RP. Clinical interview, self-report, and geospatial assessments will be administered at pre- and post-treatment. Select outcome and exploratory measures will be administered during treatment. Analyses will focus on trial feasibility, BA acceptability, and preliminary efficacy. Geospatial analyses will explore whether pre- to post-treatment changes in geospatial movement can be used to objectively measure treatment response. The study site and an independent Data and Safety Monitoring Board will monitor trial progress, safety, and quality. De-identified data from consenting participants will be submitted to a sponsor-designated data repository.

conclusionIf successful, this trial could help to provide veterans with AUD/PTSD with a more acceptable treatment option. Positive findings would also lay groundwork for testing BA in civilians with AUD/PTSD. Finally, by incorporating novel geospatial methods and technologies, this study could potentially yield a new approach to objectively measuring AUD/PTSD recovery that could be used in other clinical trials. This study was registered in ClinicalTrials.gov (NCT06249386).

Indexed as

AlcoholismStress Disorders, Post-TraumaticVeteransAdultBehavior TherapyFemaleHumansMalePilot ProjectsRandomized Controlled Trials as TopicSecondary PreventionAlcohol use disorderBehavioral activationGeographic information systemsPosttraumatic stress disorderRandomized controlled trialVeterans

Identifiers

PMID39186971
PMCPMC11531389

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.