ArticleProceedings of the National Academy of Sciences of the United States of America2024
Functional near-infrared spectroscopy: A novel tool for detecting consciousness after acute severe brain injury.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Research progress on occupational therapy for disorders of consciousness in the context of neurorehabilitation: visual analysis based on CiteSpace.Frontiers in neurologyPooled it
- Effects of single-modality sensory stimulation on brain function in patients with prolonged disorders of consciousness: a near-infrared spectroscopy-based study.Frontiers in neurology · 2026Trial
- Binary Classification of Consciousness Using Cerebral Blood Flow and EEG Features.Neurocritical care · 2026Article
- Early Identification of Recovery Potential After Acute Brain Injury Using Functional Near-Infrared Spectroscopy.Neurocritical care · 2026Article
- Multimodal Assessment of Consciousness with Brain-Computer Interfaces and Artificial Intelligence: From Acquired Brain Injury to Neurodegenerative Disease.Journal of clinical medicine · 2026Review
- Single-subject detection of speech network activation using functional near-infrared spectroscopy.Neurophotonics · 2026Article
- Advances in Wearable Bioimaging.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Depth-sensitive cerebral blood flow and low-frequency oscillations for consciousness assessment using time-domain diffuse correlation spectroscopy.Neurophotonics · 2026Article
- Near-Infrared Spectroscopy to Assess Covert Volitional Brain Activity in Intensive Care.Neurocritical care · 2026Article
- Acute prefrontal hemodynamic responses to Xingnao Kaiqiao acupuncture in healthy participants and patients with prolonged disorders of consciousness.Frontiers in neurology · 2026Article
- Immediate large-scale cortical network changes following acupuncture in patients with disorders of consciousness: a resting-state fNIRS study.Frontiers in neuroscience · 2026Article
- Early Detection of Covert Consciousness With Functional Near-Infrared Spectroscopy.Annals of neurology · 2025Article
- Parkinson's disease participant-led research: Towards neuroimaging-assisted deep brain stimulation programming.Journal of Parkinson's disease · 2025Article
- Detecting Awareness in the Intensive Care Unit Using Functional Near-Infrared Spectroscopy.Annals of neurology · 2025Article
- Emerging issues in the management of patients with disorders of consciousness.Journal of neurology · 2025Review
- Functional connectivity in whole-brain and network analysis differentiates minimally conscious from unresponsive patients: a resting-state fNIRS study.Journal of translational medicine · 2025Article
- Sensitive and specific fNIRS-based approach for awareness detection in disorders of consciousness: proof of principle in healthy adults.Neurophotonics · 2025Article
- Functional Near-Infrared Spectroscopy in Schizophrenia Research: Progress, Challenges, and Future Directions.Medical science monitor : international medical journal of experimental and clinical research · 2025Review
- Functional neuroimaging in disorders of consciousness: towards clinical implementation.Brain : a journal of neurology · 2025Review
- EEG Response to Sedation Interruption Complements Behavioral Assessment After Severe Brain Injury.Annals of clinical and translational neurology · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Recent advancements in functional neuroimaging have demonstrated that some unresponsive patients in the intensive care unit retain a level of consciousness that is inconsistent with their behavioral diagnosis of awareness. Functional near-infrared spectroscopy (fNIRS) is a portable optical neuroimaging method that can be used to measure neural activity with good temporal and spatial resolution. However, the reliability of fNIRS for detecting the neural correlates of consciousness remains to be established. In a series of studies, we evaluated whether fNIRS can record sensory, perceptual, and command-driven neural processing in healthy participants and in behaviorally nonresponsive patients. At the individual healthy subject level, we demonstrate that fNIRS can detect commonly studied resting state networks, sensorimotor processing, speech-specific auditory processing, and volitional command-driven brain activity to a motor imagery task. We then tested fNIRS with three acutely brain injured patients and found that one could willfully modulate their brain activity when instructed to imagine playing a game of tennis-providing evidence of preserved consciousness despite no observable behavioral signs of awareness. The successful application of fNIRS for detecting preserved awareness among behaviorally nonresponsive patients highlights its potential as a valuable tool for uncovering hidden cognitive states in critical care settings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.