Evidence map›Paper›PMID 39186657›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Paula Pelayo, Fatima A Hussain, Caroline A Werlang, Chloe M Wu, Benjamin M Woolston, Claire M Xiang, Lindsay Rutt, Michael T France, Jacques Ravel, Katharina Ribbeck and 2 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Article
  2. The redefined identity ofJournal of bacteriology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Anaerobe-Driven Inflammation and Epithelial Barrier Disruption in Genital HIV Acquisition.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026
    Review
  7. Review
  8. Spatial organization ofInfection and immunity · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Frontiers in reproductive health · 2026
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Sialidases derived frombioRxiv : the preprint server for biology · 2025
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Paula PelayoDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138.ORCID 0009-0004-1508-2034
Fatima A HussainRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard, Massachusetts General Hospital, Cambridge, MA 02139.
Caroline A WerlangDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
Chloe M WuDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
Benjamin M WoolstonDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138.
Claire M XiangDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138.ORCID 0000-0003-0499-1895
Lindsay RuttInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201.
Michael T FranceInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201.
Jacques RavelInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201.ORCID 0000-0002-0851-2233
Katharina RibbeckDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139.
Douglas S KwonRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard, Massachusetts General Hospital, Cambridge, MA 02139.ORCID 0000-0001-8521-8735
Emily P BalskusDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138.ORCID 0000-0001-5985-5714

Funding

Multidisciplinary HIV Training ProgramT32AI007387 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Daniel R. Kuritzkes · 1990 to 2026
$8.8M
Bill and Melinda Gates Foundation (GF) INV-048977 and OPP1189208Bill and Melinda Gates Foundation (GF) No. 270790 and INV-037720NIAID NIH HHS T32 AI007387NSF | National Science Foundation Graduate Research Fellowship Program (GRFP) DGE 1745303
6 · The paper itself

Abstract

Elevated bacterial sialidase activity in the female genital tract is strongly associated with poor health outcomes including preterm birth and bacterial vaginosis (BV). These negative effects may arise from sialidase-mediated degradation of the protective mucus layer in the cervicovaginal environment. Prior biochemical studies of vaginal bacterial sialidases have focused solely on the BV-associated organism

Indexed as

MicrobiotaNeuraminidasePrevotellaVaginaBacterial ProteinsFemaleHumansMucinsVaginosis, BacterialBacterial ProteinsMucinsNeuraminidasebacterial vaginosismucinPrevotellasialidasevaginal microbiome

Identifiers

PMID39186657
PMCPMC11388281

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.