ArticleEuropean radiology experimental2024
Assessment of thoracic disc degeneration using dual-energy CT-based collagen maps.
Article in European radiology experimental, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Quantification of intervertebral disc degeneration using dual-energy computed tomography collagen maps: a comparative study with MRI Pfirrmann grading.Scientific reports · 2026Article
- Detection of lumbar disc herniation and degeneration using photon-counting detector CT with virtual non-calcium imaging.European radiology · 2026Article
- Hemilaminectomy versus laminoplasty for intradural extramedullary tumors: A comparison of postoperative axial pain and regional outcomes.Brain & spine · 2026Article
- Spectral CT electron density for evaluation of lumbar intervertebral disk degeneration.PloS one · 2026Article
- Assessment of Intervertebral Lumbar Disk Herniation: Accuracy of Dual-Energy CT Compared to MRI.Journal of clinical medicine · 2025Article
- Dual-energy computed tomography collagen density mapping of the temporomandibular disc.BMC medical imaging · 2025Article
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18 authors.
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Abstract
backgroundWe evaluated the role of dual-energy computed tomography (DECT)-based collagen maps in assessing thoracic disc degeneration.
methodsWe performed a retrospective analysis of patients who underwent DECT and magnetic resonance imaging (MRI) of the thoracic spine within a 2-week period from July 2019 to October 2022. Thoracic disc degeneration was classified by three blinded radiologists into three Pfirrmann categories: no/mild (grade 1-2), moderate (grade 3-4), and severe (grade 5). The DECT performance was determined using MRI as a reference standard. Interreader reliability was assessed using intraclass correlation coefficient (ICC). Five-point Likert scales were used to assess diagnostic confidence and image quality.
resultsIn total, 612 intervertebral discs across 51 patients aged 68 ± 16 years (mean ± standard deviation), 28 males and 23 females, were assessed. MRI revealed 135 no/mildly degenerated discs (22.1%), 470 moderately degenerated discs (76.8%), and 7 severely degenerated discs (1.1%). DECT collagen maps achieved an overall accuracy of 1,483/1,838 (80.8%) for thoracic disc degeneration. Overall recall (sensitivity) was 331/405 (81.7%) for detecting no/mild degeneration, 1,134/1,410 (80.4%) for moderate degeneration, and 18/21 (85.7%) for severe degeneration. Interrater agreement was good (ICC = 0.89). Assessment of DECT-based collagen maps demonstrated high diagnostic confidence (median 4; interquartile range 3-4) and good image quality (median 4; interquartile range 4-4).
conclusionDECT showed an overall 81% accuracy for disc degeneration by visualizing differences in the collagen content of thoracic discs. RELEVANCE STATEMENT: Utilizing DECT-based collagen maps to distinguish various stages of thoracic disc degeneration could be clinically relevant for early detection of disc-related conditions. This approach may be particularly beneficial when MRI is contraindicated. KEY POINTS: A total of 612 intervertebral discs across 51 patients were retrospectively assessed with DECT, using MRI as a reference standard. DECT-based collagen maps allowed thoracic disc degeneration assessment achieving an overall 81% accuracy with good interrater agreement (ICC = 0.89). DECT-based collagen maps could be a good alternative in the case of contraindications to MRI.
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