Evidence map›Paper›PMID 39185808›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2024

Dual-Function Nanoscale Coordination Polymer Nanoparticles for Targeted Diagnosis and Therapeutic Delivery in Atherosclerosis.

Yuanzhe Lin, Jingjing Liu, Suet Yen Chong, Hui Jun Ting, Xichuan Tang, Liqiang Yang, Sitong Zhang, Xinyi Qi, Peng Pei, Zhigao Yi and 8 more

Abstract read
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Review
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  13. Polymeric Nanomaterials for Atherosclerosis Diagnosis and Treatment.Polymer science & technology (Washington, D.C.) · 2025
    Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. How Advanced Is Nanomedicine for Atherosclerosis?International journal of nanomedicine · 2025
    Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Yuanzhe LinDepartment of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Rd, Singapore, 119228, Singapore.ORCID 0009-0003-2360-4739
Jingjing LiuInstitute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu, 225001, China.
Suet Yen ChongDepartment of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Rd, Singapore, 119228, Singapore.ORCID 0000-0002-3627-4025
Hui Jun TingDepartment of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Rd, Singapore, 119228, Singapore.
Xichuan TangDepartment of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Rd, Singapore, 119228, Singapore.
Liqiang YangDepartment of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Rd, Singapore, 119228, Singapore.
Sitong ZhangDepartment of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Rd, Singapore, 119228, Singapore.
Xinyi QiDepartment of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Rd, Singapore, 119228, Singapore.
Peng PeiDepartment of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Rd, Singapore, 119228, Singapore.
Zhigao YiDepartment of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543, Singapore.
Chenyuan HuangDepartment of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Rd, Singapore, 119228, Singapore.ORCID 0000-0002-1812-7283
Xiao HouDepartment of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Rd, Singapore, 119228, Singapore.
Liang GaoDepartment of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117596, Singapore.
Federico TortaDepartment of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117596, Singapore.
Xiaogang LiuDepartment of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543, Singapore.
Bin LiuDepartment of Chemical and Biomolecular Engineering, National University of Singapore, Singapore, 117585, Singapore.
James Chen Yong KahDepartment of Biomedical Engineering, National University of Singapore, 4 Engineering Drive 3, Block E4, #04-08, Singapore, 117583, Singapore.ORCID 0000-0002-2247-6929
Jiong-Wei WangDepartment of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Rd, Singapore, 119228, Singapore.ORCID 0000-0001-7986-6082

Funding

Society for Epidemiologic Research Doctoral Dissertation WorkshopR13TR002021 · NCATS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI HARLOW, BERNARD L · 2017 to 2018
$46k
National Medical Research Council MOH-OFIRG21nov-0010National Medical Research Council Centre NMRC CG21APR1008National University Health System Seed Fund NUHSRO/2018/095/RO5+5/Seed-Nov/05National University of Singapore CFGFY20P14NUS NanoNASH Program NUHSRO/2020/002/NanoNash/LOANUS Yong Loo Lin School of Medicine Nanomedicine Translational Research Program NUHSRO/2021/034/TRP/09/Nanomedicine
6 · The paper itself

Abstract

Atherosclerosis is the primary cause of cardiovascular events such as heart attacks and strokes. However, current medical practice lacks non-invasive, reliable approaches for both imaging atherosclerotic plaques and delivering therapeutic agents directly therein. Here, a biocompatible and biodegradable pH-responsive nanoscale coordination polymers (NCPs) based theranostic system is reported for managing atherosclerosis. NCPs are synthesized with a pH-responsive benzoic-imine (BI) linker and Gd

Indexed as

AtherosclerosisNanoparticlesPolymersAnimalsDrug Delivery SystemsGadoliniumHydrogen-Ion ConcentrationMagnetic Resonance ImagingMicePolyethylene GlycolsSimvastatinGadoliniumPolyethylene GlycolsPolymersSimvastatinatherosclerosismagnetic resonance imagingnanoscale coordination polymerspH‐responsivetheranostic

Identifiers

PMID39185808
PMCPMC11579969

What OpenQuestion holds

Texttitle and abstract
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.