Evidence map›Paper›PMID 39185485›Full record

ArticleJGH open : an open access journal of gastroenterology and hepatology2024

Steatosis, inflammation, fibroprogression, and cirrhosis in remnant liver post-liver donation.

Jeby Jacob, Amal Joseph, Harikumar R Nair, Geevarghese Prajob Prasad, Vijosh V Kumar, Lekshmi Thattamuriyil Padmakumari

Abstract read
In one paragraph

Article in JGH open : an open access journal of gastroenterology and hepatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jeby JacobDepartment of Liver & Digestive Care Apollo Adlux Hospital Ernakulam Kerala India.ORCID https://orcid.org/0000-0003-0164-9752
Amal JosephDepartment of Gastroenterology and Hepatology Ernakulam Medical Centre Kochi Kerala India.ORCID https://orcid.org/0009-0004-8617-1229
Harikumar R NairDepartment of Gastroenterology and Hepatology Ernakulam Medical Centre Kochi Kerala India.ORCID https://orcid.org/0000-0001-6075-9236
Geevarghese Prajob PrasadDepartment of Liver & Digestive Care Apollo Adlux Hospital Ernakulam Kerala India.ORCID https://orcid.org/0000-0003-4039-932X
Vijosh V KumarDepartment of Liver & Digestive Care Apollo Adlux Hospital Ernakulam Kerala India.ORCID https://orcid.org/0000-0002-3829-1291
Lekshmi Thattamuriyil PadmakumariDepartment of Radiology Apollo Adlux Hospital Ernakulam Kerala India.ORCID https://orcid.org/0000-0002-6725-6997

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aim: This is a cross-sectional observational study conducted on living liver donors focusing on "long-term remnant liver health" specifically looking at steatosis, inflammation, and fibrosis using multiparametric ultra sonological evaluation and noninvasive blood tests. Methods: Multiparametric ultrasound evaluation included assessment of shear wave elastography (fibrosis), sound speed plane wave ultrasound, attenuation plane wave ultrasound (steatosis), and viscosity plane wave ultrasound (inflammation). Blood test based APRI and FIB-4 were calculated. Liver biopsy was performed if noninvasive evaluation pointed toward clinically relevant fibro progression (F4). Results: Out of 36 donors, significant fibrosis (>F2) was found in 11 donors (30.5%), seven donors (19.4%) had severe fibrosis (>F3), and two donors had shear wave elastography values suggestive of cirrhosis(F4). Of these two, one donor was extensively evaluated and was found to have biopsy proven cirrhosis with endoscopic evidence of portal hypertension. The prevalence of fatty liver disease in our study group was 50%. Conclusion: We report the first liver donor cohort with fibroprogression and cirrhosis occurring in the remnant liver. Our donor cohort with a significant proportion having steatosis and fibroprogression underscores the importance of regular follow-up of liver donors and evaluation of remnant liver.

Indexed as

cirrhosisfatty livernon alcoholic fatty liver disease

Identifiers

PMID39185485
PMCPMC11342348

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.