Evidence map›Paper›PMID 39185284›Full record

ArticleResuscitation plus2024

The effects of bolus compared to continuous administration of adrenaline on cerebral oxygenation during experimental cardiopulmonary resuscitation.

Julian Wagner, Simon Mathis, Patrick Spraider, Julia Abram, Stefanie Baldauf, Daniel Pinggera, Marlies Bauer, Tobias Hell, Pia Tscholl, Bernhard Glodny and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Resuscitation plus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Julian WagnerDepartment of Anaesthesia and Intensive Care Medicine, Medical University of Innsbruck, Austria.
Simon MathisDepartment of Anaesthesia and Intensive Care Medicine, Medical University of Innsbruck, Austria.
Patrick SpraiderDepartment of Anaesthesia and Intensive Care Medicine, Medical University of Innsbruck, Austria.
Julia AbramDepartment of Anaesthesia and Intensive Care Medicine, Medical University of Innsbruck, Austria.
Stefanie BaldaufDepartment of Anaesthesia and Intensive Care Medicine, Medical University of Innsbruck, Austria.
Daniel PinggeraDepartment of Neurosurgery, Medical University of Innsbruck, Austria.
Marlies BauerDepartment of Neurosurgery, Medical University of Innsbruck, Austria.
Tobias HellData Lab Hell, Innsbruck, Austria.
Pia TschollDepartment of Subject-Specific Education, University of Innsbruck, Austria.
Bernhard GlodnyDepartment of Radiology, Medical University of Innsbruck, Austria.
Raimund HelbokDepartment of Neurology, Medical University of Innsbruck, Austria.
Peter MairDepartment of Anaesthesia and Intensive Care Medicine, Medical University of Innsbruck, Austria.
Judith MartiniDepartment of Anaesthesia and Intensive Care Medicine, Medical University of Innsbruck, Austria.
Gabriel PutzerDepartment of Anaesthesia and Intensive Care Medicine, Medical University of Innsbruck, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Bolus administration of adrenaline during cardiopulmonary resuscitation (CPR) results in only short-term increases in systemic and cerebral perfusion pressure (CePP) with unclear effects on cerebral oxygenation. The aim of this study was to investigate the effects of bolus compared to continuous adrenaline administration on cerebral oxygenation in a porcine CPR model. Methods: After five minutes of cardiac arrest, mechanical CPR was performed for 15 min. Adrenaline (45 μg/kg) was administered either as a bolus every five minutes or continuously over the same period via an infusion pump. Main outcome parameter was brain tissue oxygen tension (P Results: During CPR, mean MAP (45 ± 8 mmHg vs. 38 ± 8 mmHg; Conclusion: Continuous administration of adrenaline improved brain tissue oxygen tension compared with bolus administration during prolonged CPR.

Indexed as

AdrenalineAdvanced cardiac life supportBrain oxygenationCardiac arrestCardiopulmonary resuscitationCerebral perfusion pressureEpinephrineIntracranial pressureNear infrared spectroscopyOxygen/bloodPigs

Identifiers

PMID39185284
PMCPMC11343046

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.