Evidence map›Paper›PMID 39185245›Full record

ArticlebioRxiv : the preprint server for biology2024

Restoration of Type 17 immune signaling is not sufficient for protection during influenza-associated pulmonary aspergillosis.

Aijaz Ahmad, Ravineel Bhan Singh, Kara Nickolich, Matthew Pilewski, Caden Ngeow, Kwame Frempong-Manso, Keven Robinson

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Aijaz AhmadDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0003-2845-0727
Ravineel Bhan SinghDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Kara NickolichDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Matthew PilewskiDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Caden NgeowDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Kwame Frempong-MansoDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Keven RobinsonDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID 0000-0001-7558-4002

Funding

Influenza Attenuates Innate Pulmonary Host Defense against Invasive Pulmonary AspergillosisR01AI153337 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ROBINSON, KEVEN MARA · 2021 to 2025
$2.7M
Role of IL-33 in Influenza and Staphylococcus aureus Co-infectionK08HL133445 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ROBINSON, KEVEN MARA · 2016 to 2020
$800k
NHLBI NIH HHS K08 HL133445NIAID NIH HHS R01 AI153337
6 · The paper itself

Abstract

Influenza-associated pulmonary aspergillosis (IAPA) is a severe complication of influenza infection that occurs in critically ill patients and results in higher mortality compared to influenza infection alone. Interleukin-17 (IL-17) and the Type 17 immune signaling pathway cytokine family are recognized for their pivotal role in fostering protective immunity against various pathogens. In this study, we investigate the role of IL-17 and Type 17 immune signaling components during IAPA. Wild-type mice were challenged with influenza A H1N1 (Flu) and then exposed to

Indexed as

antimicrobial peptidesAspergillus fumigatusIAPAInterleukin-17

Identifiers

PMID39185245
PMCPMC11343153

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.