Evidence map›Paper›PMID 39185230›Full record

ArticlebioRxiv : the preprint server for biology2024

Co-release of GABA and ACh from medial olivocochlear neurons fine tunes cochlear efferent inhibition.

Tais Castagnola, Valeria C Castagna, Siân R Kitcher, Lester Torres Cadenas, Mariano N Di Guilmi, Maria Eugenia Gomez Casati, Paula I Buonfiglio, Viviana Dalamón, Eleonora Katz, Ana Belén Elgoyhen and 3 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Tais CastagnolaInstituto de Investigaciones en Ingeniería Genética y Biología Molecular, "Dr. Héctor N. Torres", Consejo Nacional de Investigaciones Científicas y Técnicas, (1428) Ciudad Autónoma de Buenos Aires, Argentina.ORCID 0009-0007-8762-2935
Valeria C CastagnaInstituto de Farmacología, Facultad de Medicina, Universidad de Buenos Aires, (1121) Ciudad Autónoma de Buenos Aires, Argentina.ORCID 0000-0002-1453-3372
Siân R KitcherSection on Neuronal Circuitry, National Institutes of Health, National Institute on Deafness and Other Communication Disorders, Bethesda, MD 20892, USA.ORCID 0000-0002-1881-5430
Lester Torres CadenasSection on Neuronal Circuitry, National Institutes of Health, National Institute on Deafness and Other Communication Disorders, Bethesda, MD 20892, USA.ORCID 0000-0001-5440-3030
Mariano N Di GuilmiInstituto de Investigaciones en Ingeniería Genética y Biología Molecular, "Dr. Héctor N. Torres", Consejo Nacional de Investigaciones Científicas y Técnicas, (1428) Ciudad Autónoma de Buenos Aires, Argentina.ORCID 0000-0002-3918-296X
Maria Eugenia Gomez CasatiInstituto de Farmacología, Facultad de Medicina, Universidad de Buenos Aires, (1121) Ciudad Autónoma de Buenos Aires, Argentina.ORCID 0000-0003-4923-8274
Paula I BuonfiglioInstituto de Investigaciones en Ingeniería Genética y Biología Molecular, "Dr. Héctor N. Torres", Consejo Nacional de Investigaciones Científicas y Técnicas, (1428) Ciudad Autónoma de Buenos Aires, Argentina.ORCID 0000-0003-2985-4790
Viviana DalamónInstituto de Investigaciones en Ingeniería Genética y Biología Molecular, "Dr. Héctor N. Torres", Consejo Nacional de Investigaciones Científicas y Técnicas, (1428) Ciudad Autónoma de Buenos Aires, Argentina.ORCID 0000-0001-5283-4726
Eleonora KatzInstituto de Investigaciones en Ingeniería Genética y Biología Molecular, "Dr. Héctor N. Torres", Consejo Nacional de Investigaciones Científicas y Técnicas, (1428) Ciudad Autónoma de Buenos Aires, Argentina.ORCID 0000-0002-5114-2899
Ana Belén ElgoyhenInstituto de Investigaciones en Ingeniería Genética y Biología Molecular, "Dr. Héctor N. Torres", Consejo Nacional de Investigaciones Científicas y Técnicas, (1428) Ciudad Autónoma de Buenos Aires, Argentina.ORCID 0000-0001-9487-0311
Catherine J C WeiszSection on Neuronal Circuitry, National Institutes of Health, National Institute on Deafness and Other Communication Disorders, Bethesda, MD 20892, USA.ORCID 0000-0002-2595-835X
Juan D GoutmanInstituto de Investigaciones en Ingeniería Genética y Biología Molecular, "Dr. Héctor N. Torres", Consejo Nacional de Investigaciones Científicas y Técnicas, (1428) Ciudad Autónoma de Buenos Aires, Argentina.ORCID 0000-0002-0685-0896
Carolina WedemeyerInstituto de Investigaciones en Ingeniería Genética y Biología Molecular, "Dr. Héctor N. Torres", Consejo Nacional de Investigaciones Científicas y Técnicas, (1428) Ciudad Autónoma de Buenos Aires, Argentina.ORCID 0000-0003-1757-5778

Funding

Synaptic Circuitry of Auditory NeuronsZIADC000091 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI WEISZ, CATHERINE · 2016 to 2025
$17.2M
THE CHOLINERGIC RESPONSE OF COCHLEAR HAIR CELLSR01DC001508 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI Amanda M. Lauer · 1992 to 2026
$13.2M
NIDCD NIH HHS R01 DC001508
6 · The paper itself

Abstract

During development, inner hair cells (IHCs) in the mammalian cochlea are unresponsive to acoustic stimuli but instead exhibit spontaneous activity. During this same period, neurons originating from the medial olivocochlear complex (MOC) transiently innervate IHCs, regulating their firing pattern which is crucial for the correct development of the auditory pathway. Although the MOC-IHC is a cholinergic synapse, previous evidence indicates the widespread presence of gamma-aminobutyric acid (GABA) signaling markers, including presynaptic GABA

Indexed as

auditoryco-release Gamma-Aminobutyric acid (GABA)developmentefferentmedial olivocochlear (MOC)synapse

Identifiers

PMID39185230
PMCPMC11343139

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.