Evidence map›Paper›PMID 39185212›Full record

ArticlebioRxiv : the preprint server for biology2024

The MRE11-RAD50-NBS1 complex both starts and extends DNA end resection in mouse meiosis.

Soonjoung Kim, Shintaro Yamada, Tao Li, Claudia Canasto-Chibuque, Jun Hyun Kim, Marina Marcet-Ortega, Jiaqi Xu, Diana Y Eng, Laura Feeney, John H J Petrini and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Soonjoung KimMolecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.ORCID 0009-0003-0029-4715
Shintaro YamadaMolecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.ORCID 0000-0002-4882-0871
Tao LiMolecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.ORCID 0000-0002-5728-3721
Claudia Canasto-ChibuqueMolecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.ORCID 0000-0002-0787-5892
Jun Hyun KimMolecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.ORCID 0000-0003-0196-8796
Marina Marcet-OrtegaMolecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.ORCID 0000-0002-5756-1373
Jiaqi XuMolecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.ORCID 0009-0006-6348-3769
Diana Y EngMolecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
Laura FeeneyMolecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.ORCID 0000-0002-6416-849X
John H J PetriniMolecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.ORCID 0000-0001-5102-5679
Scott KeeneyMolecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.ORCID 0000-0002-1283-6417

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Mechanism and regulation of meiotic recombinationR35GM118092 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI Scott Keeney · 2016 to 2026
$7.0M
DNA Damage & DNA Replication: a Complex RelationshipR35GM136278 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI John HJ Petrini · 2020 to 2026
$5.5M
The Mre11 complex: linking recombination to checkpointsR01GM059413 · NIGMS · UNIVERSITY OF WISCONSIN MADISON · PI PETRINI, JOHN HJ · 1999 to 2011
$5.2M
NCI NIH HHS P30 CA008748NIGMS NIH HHS R01 GM059413NIGMS NIH HHS R35 GM118092NIGMS NIH HHS R35 GM136278
6 · The paper itself

Abstract

Nucleolytic resection of DNA ends is critical for homologous recombination, but its mechanism is not fully understood, particularly in mammalian meiosis. Here we examine roles of the conserved MRN complex (MRE11, RAD50, and NBS1) through genome-wide analysis of meiotic resection in mice with various MRN mutations, including several that cause chromosomal instability in humans. Meiotic DSBs form at elevated levels but remain unresected if

Indexed as

DNA double-strand break resectionMeiosisMre11Nbs1Rad50spermatogenesisSpo11

Identifiers

PMID39185212
PMCPMC11343206

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.