Evidence map›Paper›PMID 39185209›Full record

ArticlebioRxiv : the preprint server for biology2024

Protein Carrier AAV.

Mareike D Hoffmann, Ryan J Sorensen, Ajay Extross, Yungui He, Daniel Schmidt

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mareike D HoffmannDepartment of Genetics, Cell Biology & Development, University of Minnesota, Minneapolis, MN, 55455, USA.ORCID 0000-0001-8377-1385
Ryan J SorensenDepartment of Biochemistry, Molecular Biology & Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Ajay ExtrossDepartment of Molecular, Cellular, Developmental Biology, and Genetics.
Yungui HeDepartment of Genetics, Cell Biology & Development, University of Minnesota, Minneapolis, MN, 55455, USA.
Daniel SchmidtDepartment of Genetics, Cell Biology & Development, University of Minnesota, Minneapolis, MN, 55455, USA.ORCID 0000-0001-7609-4873

Funding

Viral Innovation CoreP30DA048742 · NIDA · UNIVERSITY OF MINNESOTA · PI Mark John Thomas · 2020 to 2026
$19.0M
Viral vector technology for cell type specific gene deliveryR01GM141152 · NIGMS · UNIVERSITY OF MINNESOTA · PI SCHMIDT, DANIEL · 2022 to 2025
$1.5M
Proof of concept studies for in vivo produced CAR-T cells that target B cell follicles as a treatment for HIVR41AI184054 · NIAID · MARPAM PHARMA, LLC · PI ATHANASIOU, MARIA CONSTANCE, SCHMIDT, DANIEL · 2024 to 2024
$302k
NIAID NIH HHS R41 AI184054NIDA NIH HHS P30 DA048742NIGMS NIH HHS R01 GM141152
6 · The paper itself

Abstract

AAV is widely used for efficient delivery of DNA payloads. The extent to which the AAV capsid can be used to deliver a protein payload is unexplored. Here, we report engineered AAV capsids that directly package proteins - Protein Carrier AAV (pcAAV). Nanobodies inserted into the interior of the capsid mediate packaging of a cognate protein, including Green Fluorescent Protein (GFP),

Identifiers

PMID39185209
PMCPMC11343202

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.