Evidence map›Paper›PMID 39185175›Full record

ArticlebioRxiv : the preprint server for biology2024

Imaging high-frequency voltage dynamics in multiple neuron classes of behaving mammals.

Simon Haziza, Radosław Chrapkiewicz, Yanping Zhang, Vasily Kruzhilin, Jane Li, Jizhou Li, Geoffroy Delamare, Rachel Swanson, György Buzsáki, Madhuvanthi Kannan and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Simon HazizaJames H. Clark Center, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0001-5051-8148
Radosław ChrapkiewiczJames H. Clark Center, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-9923-4274
Yanping ZhangJames H. Clark Center, Stanford University, Stanford, CA 94305, USA.
Vasily KruzhilinJames H. Clark Center, Stanford University, Stanford, CA 94305, USA.
Jane LiJames H. Clark Center, Stanford University, Stanford, CA 94305, USA.
Jizhou LiHoward Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-7399-1349
Geoffroy DelamareCNC Program, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0001-6217-4370
Rachel SwansonNeuroscience Institute, Langone Medical Center, New York University, New York, NY 10016, USA.
György BuzsákiNeuroscience Institute, Langone Medical Center, New York University, New York, NY 10016, USA.ORCID 0000-0002-3100-4800
Madhuvanthi KannanDepartment of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0003-0664-7377
Ganesh VasanDepartment of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-6612-7739
Michael Z LinDepartments of Bioengineering & Pediatrics, Stanford University, Stanford CA 94305, USA.ORCID 0000-0002-0492-1961
Hongkui ZengAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0002-0326-5878
Tanya L DaigleAllen Institute for Brain Science, Seattle, WA 98109, USA.ORCID 0000-0001-9700-8452
Mark J SchnitzerJames H. Clark Center, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-1431-8533

Funding

Towards a Complete Description of the Circuitry Underlying Sharp Wave-Mediated Memory ReplayU19NS104590 · NINDS · STANFORD UNIVERSITY · PI LOSONCZY, ATTILA · 2017 to 2021
$13.2M
Multi-color optical voltage imaging of neural activity in behaving animalsU01NS120822 · NINDS · STANFORD UNIVERSITY · PI SCHNITZER, MARK J, VASAN, GANESH · 2021 to 2025
$3.3M
Transgenic mice and multiplexed, multi-beam instrumentation for large-scale optical experiments on brain states and ensemble cellular dynamics in behaving animalsUF1NS107610 · NINDS · STANFORD UNIVERSITY · PI SCHNITZER, MARK J, ZENG, HONGKUI · 2018 to 2018
$2.9M
Nikon A1Rsi resonant spectral confocal microscopeS10OD010580 · OD · STANFORD UNIVERSITY · PI FULLER, MARGARET T · 2013 to 2013
$377k
NIH HHS S10 OD010580NINDS NIH HHS U01 NS120822NINDS NIH HHS U19 NS104590NINDS NIH HHS UF1 NS107610
6 · The paper itself

Abstract

Fluorescent genetically encoded voltage indicators report transmembrane potentials of targeted cell-types. However, voltage-imaging instrumentation has lacked the sensitivity to track spontaneous or evoked high-frequency voltage oscillations in neural populations. Here we describe two complementary TEMPO voltage-sensing technologies that capture neural oscillations up to ~100 Hz. Fiber-optic TEMPO achieves ~10-fold greater sensitivity than prior photometry systems, allows hour-long recordings, and monitors two neuron-classes per fiber-optic probe in freely moving mice. With it, we uncovered cross-frequency-coupled theta- and gamma-range oscillations and characterized excitatory-inhibitory neural dynamics during hippocampal ripples and visual cortical processing. The TEMPO mesoscope images voltage activity in two cell-classes across a ~8-mm-wide field-of-view in head-fixed animals. In awake mice, it revealed sensory-evoked excitatory-inhibitory neural interactions and traveling gamma and 3-7 Hz waves in the visual cortex, and previously unreported propagation directions for hippocampal theta and beta waves. These technologies have widespread applications probing diverse oscillations and neuron-type interactions in healthy and diseased brains.

Identifiers

PMID39185175
PMCPMC11343216

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.