Evidence map›Paper›PMID 39185156›Full record

ArticlebioRxiv : the preprint server for biology2024

Identifying a gene signature of metastatic potential by linking pre-metastatic state to ultimate metastatic fate.

Jesse S Handler, Zijie Li, Rachel K Dveirin, Weixiang Fang, Hani Goodarzi, Elana J Fertig, Reza Kalhor

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Jesse S HandlerDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0001-5444-3905
Zijie LiDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0009-0001-2485-1980
Rachel K DveirinDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0003-0453-503X
Weixiang FangDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-1152-7508
Hani GoodarziDepartment of Biochemistry & Biophysics, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0002-9648-8949
Elana J FertigDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0003-3204-342X
Reza KalhorDepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-5558-7545

Funding

Wilmer Core Grant for Vision ResearchP30EY001765 · NEI · JOHNS HOPKINS UNIVERSITY · PI Ji Yi · 1985 to 2026
$22.1M
ONCOLOGY: CHEMOTHERAPY, IMMUNOLOGY, BIOLOGYT32CA009071 · NCI · JOHNS HOPKINS UNIVERSITY · PI Mary Y Armanios, Nilofer S. Azad · 1985 to 2026
$12.8M
Dynamics of lineage-specific genome reorganization in gastrulation and their response to disease-associated epigenetic perturbationsU01HL156056 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KALHOR, REZA · 2020 to 2024
$3.1M
Mapping the dynamics of mouse neurogenesis in autism models using high-resolution genomic barcoding technologiesR01HG012357 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI KALHOR, REZA · 2022 to 2025
$2.1M
NCI NIH HHS T32 CA009071NEI NIH HHS P30 EY001765NHGRI NIH HHS R01 HG012357NHLBI NIH HHS U01 HL156056
6 · The paper itself

Abstract

Identifying the key molecular pathways that enable metastasis by analyzing the eventual metastatic tumor is challenging because the state of the founder subclone likely changes following metastatic colonization. To address this challenge, we labeled primary mouse pancreatic ductal adenocarcinoma (PDAC) subclones with DNA barcodes to characterize their pre-metastatic state using ATAC-seq and RNA-seq and determine their relative

Identifiers

PMID39185156
PMCPMC11343111

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.