Evidence map›Paper›PMID 39185155›Full record

ArticlebioRxiv : the preprint server for biology2024

Distinct evolutionary trajectories following loss of RNA interference in

Jun Huang, Connor J Larmore, Shelby J Priest, Ziyan Xu, Fred S Dietrich, Vikas Yadav, Paul M Magwene, Sheng Sun, Joseph Heitman

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Jun HuangDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.ORCID 0000-0002-4071-0926
Connor J LarmoreDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.ORCID 0000-0002-5341-7788
Shelby J PriestDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.ORCID 0000-0003-4577-167X
Ziyan XuDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.ORCID 0009-0001-7055-9788
Fred S DietrichDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.
Vikas YadavDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.ORCID 0000-0003-2650-9035
Paul M MagweneDepartment of Biology, Duke University, Durham, NC 27710, USA.ORCID 0000-0002-7659-2589
Sheng SunDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.ORCID 0000-0002-2895-1153
Joseph HeitmanDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.ORCID 0000-0001-6369-5995

Funding

Rapid production of SARS-CoV-2 molecular clones using CRISPR-based yeast recombineeringR01AI100272 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MADHANI, HITEN D · 2012 to 2025
$11.3M
Structure, function, and evolution of the Cryptococcus MAT locusR01AI050113 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 2002 to 2024
$8.5M
ROLE OF CALCINEURIN IN C. NEOFORMANS MATING AND FRUITINGR01AI039115 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 1997 to 2025
$6.7M
Genetics of Cryptococcus sexual reproductionR37AI039115 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 2011 to 2020
$4.9M
The Genetic Basis of Virulence in Cryptococcus NeoformansR01AI133654 · NIAID · DUKE UNIVERSITY · PI JOSEPH HEITMAN, Paul Mitaari Magwene · 2017 to 2026
$4.7M
NIAID NIH HHS R01 AI039115NIAID NIH HHS R01 AI050113NIAID NIH HHS R01 AI100272NIAID NIH HHS R01 AI133654NIAID NIH HHS R37 AI039115
6 · The paper itself

Abstract

While increased mutation rates typically have negative consequences in multicellular organisms, hypermutation can be advantageous for microbes adapting to the environment. Previously, we identified two hypermutator

Indexed as

Antifungal drug resistanceBiological SciencesGeneticsHypermutationKDZ transposon

Identifiers

PMID39185155
PMCPMC11343200

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.