Evidence map›Paper›PMID 39185150›Full record

ArticlebioRxiv : the preprint server for biology2024

Identification of In Vivo Internalizing Cardiac-Specific RNA Aptamers.

Chandan Narayan, Li-Hsien Lin, Maya N Barros, Trent C Gilbert, Caroline R Brown, Dominic Reddin, Barry London, Yani Chen, Mary E Wilson, Jennifer Streeter and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chandan NarayanDepartment of Internal Medicine, University of Iowa, Iowa City, IA, USA.
Li-Hsien LinDepartment of Internal Medicine, University of Iowa, Iowa City, IA, USA.
Maya N BarrosDepartment of Internal Medicine, University of Iowa, Iowa City, IA, USA.
Trent C GilbertCarver College of Medicine, University of Iowa, Iowa City, IA, USA.
Caroline R BrownCarver College of Medicine, University of Iowa, Iowa City, IA, USA.
Dominic ReddinDepartment of Internal Medicine, University of Iowa, Iowa City, IA, USA.
Barry LondonDepartment of Internal Medicine, University of Iowa, Iowa City, IA, USA.
Yani ChenDepartment of Internal Medicine, University of Iowa, Iowa City, IA, USA.
Mary E WilsonDepartment of Internal Medicine, University of Iowa, Iowa City, IA, USA.
Jennifer StreeterDepartment of Internal Medicine, University of Iowa, Iowa City, IA, USA.
William H ThielDepartment of Internal Medicine, University of Iowa, Iowa City, IA, USA.

Funding

Leveraging the mitochondrial regulator MIRO1 to prevent neointimal hyperplasiaR01HL157956 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI GRUMBACH, ISABELLA MARIA · 2022 to 2025
$2.4M
Deciphering mechanisms of vascular disease with cell and process specific ligandsR01HL139581 · NHLBI · UNIVERSITY OF IOWA · PI THIEL, WILLIAM H · 2018 to 2022
$1.9M
Medical Student Summer Research ProgramT35HL166206 · NHLBI · UNIVERSITY OF IOWA · PI ROBERT D ROGHAIR · 2023 to 2026
$598k
The Role of Exosomes in the Pathogenesis of LeishmaniasisI01BX000536 · VA · IOWA CITY VA MEDICAL CENTER · PI WILSON, MARY E · 2009 to 2023
–
Innate inflammatory cells in leishmaniasisI01BX001983 · VA · IOWA CITY VA MEDICAL CENTER · PI WILSON, MARY E · 2014 to 2022
–
BLRD VA I01 BX000536BLRD VA I01 BX001983NHLBI NIH HHS R01 HL139581NHLBI NIH HHS R01 HL157956NHLBI NIH HHS T35 HL166206
6 · The paper itself

Abstract

Background: The pursuit of selective therapeutic delivery to target tissue types represents a key goal in the treatment of a range of adverse health issues, including diseases afflicting the heart. The development of new cardiac-specific ligands is a crucial step towards effectively targeting therapeutics to the heart. Methods: Utilizing an Results: The Conclusions: These findings suggest that CA1 and CA41 have the potential to be promising candidates for targeted drug delivery and imaging applications in cardiac diseases.

Indexed as

aptamercardiomyocyte targeting ligandsSELEX

Identifiers

PMID39185150
PMCPMC11343129

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.