Evidence map›Paper›PMID 39185035›Full record

ArticleVeterinary world2024

Effect of neem leaf extract (

Zainabur Rahmah, Kautsar Citra Nirmala, Ach Nashichuddin, Riskiyana Riskiyana, Alvi Milliana, Nurfianti Indriana, Lina Fitria Astari, Prida Ayudianti, Munawar Kholil

Abstract read
In one paragraph

Article in Veterinary world, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zainabur RahmahDepartment of Parasitology, Faculty of Medicine and Health Sciences, Universitas Islam Negeri Maulana Malik Ibrahim Malang, Indonesia.
Kautsar Citra NirmalaMedicine Study Program, Faculty of Medicine and Health Sciences, Universitas Islam Negeri Maulana Malik Ibrahim Malang, Indonesia.
Ach NashichuddinDepartment of Mathematics, Faculty of Science and Technology, Universitas Islam Negeri Maulana Malik Ibrahim Malang, Indonesia.
Riskiyana RiskiyanaDepartment of Neurology, Faculty of Medicine and Health Sciences, Universitas Islam Negeri Maulana Malik Ibrahim Malang, Indonesia.
Alvi MillianaDepartment of Microbiology, Faculty of Medicine, and Health Sciences, Universitas Islam Negeri Maulana Malik Ibrahim Malang, Indonesia.
Nurfianti IndrianaDepartment of Obstetrics and Gynecology, Faculty of Medicine, and Health Sciences, Universitas Islam Negeri Maulana Malik Ibrahim Malang, Indonesia.
Lina Fitria AstariDepartment of Child Health, Faculty of Medicine, and Health Sciences, Universitas Islam Negeri Maulana Malik Ibrahim Malang, Indonesia.
Prida AyudiantiDepartment of Dermatology and Venereology, Faculty of Medicine, and Health Sciences, Universitas Islam Negeri Maulana Malik Ibrahim Malang, Indonesia.
Munawar KholilDepartment of Agriculture Product Technology, Politeknik Negeri Ketapang, Ketapang, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aim: Brain malaria, which results from Materials and Methods: 13-16 weeks old C57BL mice received infection by Results: Neem leaf extract reduces parasitemia and neuron cell apoptosis at multiple dosages (p < 0.000). Apoptosis in brain neurons and parasitemia show a strong positive correlation (r = +0.939). Neem leaf extract at doses of 12 and 16 mg was the most effective in reducing parasitemia levels and causing cell death. Conclusions: Neem leaf therapy significantly reduced the degree of parasitemia and cell apoptosis in C57BL mice compared with the control group without treatment (p = 0.05). This shows that neem leaves have the potential to be a candidate drug for malaria.

Indexed as

apoptosisAzadirachta indicacerebral malarianeem leavesparasitemia

Identifiers

PMID39185035
PMCPMC11344125

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.