Evidence map›Paper›PMID 39184962›Full record

ArticleIEEE open journal of engineering in medicine and biology2024

Digital Twins of Biological Systems: A Narrative Review.

Ghufran A Alsalloum, Nour M Al Sawaftah, Kelly M Percival, Ghaleb A Husseini

Abstract read
In one paragraph

Article in IEEE open journal of engineering in medicine and biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. From genes to germ layers: virtual twins of gastruloids.NPJ systems biology and applications · 2026
    Review
  5. Digital Twin Technology In Radiology.Journal of imaging informatics in medicine · 2026
    Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ghufran A AlsalloumDepartment of Biosciences and Bioengineering, College of EngineeringAmerican University of Sharjah Sharjah 26666 UAE.ORCID https://orcid.org/0000-0002-1610-9807
Nour M Al SawaftahDepartment of Material Science and Engineering, College of EngineeringAmerican University of Sharjah Sharjah 26666 UAE.
Kelly M PercivalDepartment of Chemical and Biological Engineering, College of EngineeringAmerican University of Sharjah Sharjah 26666 UAE.
Ghaleb A HusseiniDepartment of Chemical and Biological Engineering, College of EngineeringAmerican University of Sharjah Sharjah 26666 UAE.ORCID https://orcid.org/0000-0002-7244-3105

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The concept of Digital Twins (DTs), software models that mimic the behavior and interactions of physical or conceptual objects within their environments, has gained traction in recent years, particularly in medicine and healthcare research. DTs technology emerges as a pivotal tool in disease modeling, integrating diverse data sources to computationally model dynamic biological systems. This narrative review explores potential DT applications in medicine, from defining DTs and their history to constructing DTs, modeling biologically relevant systems, as well as discussing the benefits, risks, and challenges in their application. The influence of DTs extends beyond healthcare and can revolutionize healthcare management, drug development, clinical trials, and various biomedical research fields.

Indexed as

Biological system modelingdigital twinmedical technology

Identifiers

PMID39184962
PMCPMC11342927

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.