Evidence map›Paper›PMID 39184533›Full record

ArticleRheumatology advances in practice2024

Exploring the association between circulating endothelial protein C receptor and disease activity of rheumatoid arthritis in a pilot study.

Meilang Xue, Haiyan Lin, Tom Lynch, Lara Bereza-Malcolm, Premarani Sinnathurai, Ranjeny Thomas, Helen Keen, Catherine Hill, Susan Lester, Mihir Wechalekar and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Rheumatology advances in practice, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Meilang XueSutton Arthritis Research Laboratory, Sydney Musculoskeletal Health, Kolling Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.ORCID https://orcid.org/0000-0002-8563-7216
Haiyan LinSutton Arthritis Research Laboratory, Sydney Musculoskeletal Health, Kolling Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.ORCID https://orcid.org/0009-0000-6377-6410
Tom LynchThe Australian Arthritis and Autoimmune Biobank Collaborative (A3BC), Sydney Musculoskeletal Health, Kolling Institute, Faculty of Medicine and Health, The University of Sydney and the Northern Sydney Local Health District, Sydney, NSW, Australia.ORCID https://orcid.org/0000-0002-6727-6912
Lara Bereza-MalcolmSutton Arthritis Research Laboratory, Sydney Musculoskeletal Health, Kolling Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.ORCID https://orcid.org/0000-0002-8094-556X
Premarani SinnathuraiThe Australian Arthritis and Autoimmune Biobank Collaborative (A3BC), Sydney Musculoskeletal Health, Kolling Institute, Faculty of Medicine and Health, The University of Sydney and the Northern Sydney Local Health District, Sydney, NSW, Australia.ORCID https://orcid.org/0000-0002-8142-1274
Ranjeny ThomasFrazer Institute, Translational Research Institute, The University of Queensland, Brisbane, QLD, Australia.ORCID https://orcid.org/0000-0002-0518-8386
Helen KeenMedical School, The University of Western Australia, Perth, WA, Australia.ORCID https://orcid.org/0000-0002-8469-2424
Catherine HillAdelaide Medical School, The University of Adelaide, Adelaide, SA, Australia.ORCID https://orcid.org/0000-0001-8289-4922
Susan LesterAdelaide Medical School, The University of Adelaide, Adelaide, SA, Australia.ORCID https://orcid.org/0000-0003-3013-2701
Mihir WechalekarRheumatology Synovial Tissue Translational Research Group, Flinders University, Adelaide, SA, Australia.ORCID https://orcid.org/0000-0001-6668-9638
Lyn MarchThe Australian Arthritis and Autoimmune Biobank Collaborative (A3BC), Sydney Musculoskeletal Health, Kolling Institute, Faculty of Medicine and Health, The University of Sydney and the Northern Sydney Local Health District, Sydney, NSW, Australia.ORCID https://orcid.org/0000-0003-1736-8111

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: To investigate whether circulating endothelial protein C receptor (EPCR) is associated with disease activity and inflammatory markers in rheumatoid arthritis. Methods: Thirty-eight RA patients and 21 healthy controls (HC) were recruited via the A3BC biobank. Peripheral blood mononuclear cells and plasma were isolated from the blood of these participants. Plasma soluble (s)EPCR, IL-6, IL-17 and sCD14 were measured by enzyme-linked immunosorbent assay, cell membrane-associated (m)EPCR by flow cytometry; Results: RA patients had higher levels of mEPCR on T cells and plasma sEPCR compared with HC. No difference in the Conclusion: Our findings suggest that EPCR may play an important role in RA, with plasma sEPCR being potentially associated with inflammatory markers and mEPCR and the

Indexed as

endothelial protein C receptorRAsingle nucleotide polymorphismT cells

Identifiers

PMID39184533
PMCPMC11343369

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.