Evidence map›Paper›PMID 39184438›Full record

ArticleiScience2024

Miniaturized Fab' imaging probe derived from a clinical antibody: Characterization and imaging in CRISPRi-attenuated mammary tumor models.

Suresh Gupta, Rahul Pal, Eric J Schmidt, Murali Krishnamoorthy, Anita Leporati, Anand T N Kumar, Alexei Bogdanov

Abstract read
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Suresh GuptaDepartment of Radiology, UMASS Chan Medical School, Worcester, MA, USA.
Rahul PalMike Toth Head and Neck Cancer Research Center, Massachusetts Eye and Ear, Boston, MA, USA.
Eric J SchmidtDepartment of Radiology, UMASS Chan Medical School, Worcester, MA, USA.
Murali KrishnamoorthyMike Toth Head and Neck Cancer Research Center, Massachusetts Eye and Ear, Boston, MA, USA.
Anita LeporatiDepartment of Radiology, UMASS Chan Medical School, Worcester, MA, USA.
Anand T N KumarMike Toth Head and Neck Cancer Research Center, Massachusetts Eye and Ear, Boston, MA, USA.
Alexei BogdanovDepartment of Radiology, UMASS Chan Medical School, Worcester, MA, USA.

Funding

MR SIGNAL AMPLIFICATION FOR RECEPTOR IMAGINGR01EB000858 · NIBIB · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BOGDANOV, ALEXEI A. · 2003 to 2022
$6.0M
Multiplexed time domain fluorescence tomography of tumor biomarkers during immunotherapyR01CA260857 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Dan Gabriel Duda, Anand T.N. Kumar · 2021 to 2026
$2.7M
Preclinical Time domain Fluorescence Tomography PlatformR01CA211084 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI KUMAR, ANAND T.N. · 2017 to 2022
$2.6M
Fluorescence lifetime-based tumor contrast enhancement using exogenous probesR01DE033427 · NIDCR · MASSACHUSETTS GENERAL HOSPITAL · PI Anand T.N. Kumar · 2023 to 2026
$1.9M
NCI NIH HHS R01 CA211084NCI NIH HHS R01 CA260857NIBIB NIH HHS R01 EB000858NIDCR NIH HHS R01 DE033427
6 · The paper itself

Abstract

Clinical imaging-assisted oncosurgical navigation requires cancer-specific miniaturized optical imaging probes. We report a near-infrared (NIR) Fab'-based epidermal growth factor receptor (EGFR)-specific probe carrying 3 NIR fluorophores (Fab'-800CW), which retained high-affinity binding to EGFR ectodomain (equilibrium K

Indexed as

CancerMedical imagingSurgery

Identifiers

PMID39184438
PMCPMC11342199

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.