Evidence map›Paper›PMID 39184360›Full record

ArticleACS measurement science au2024

Establishing Quality Control Metrics for Large-Scale Plasma Proteomic Sample Preparation.

Nekesa C Oliver, Min Ji Choi, Albert B Arul, Marsalas D Whitaker, Renã A S Robinson

Abstract read
In one paragraph

Article in ACS measurement science au, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nekesa C OliverDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States.
Min Ji ChoiDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States.
Albert B ArulDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States.
Marsalas D WhitakerDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States.
Renã A S RobinsonDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, United States.ORCID https://orcid.org/0000-0001-6307-8671

Funding

Southern Community Cohort StudyU01CA202979 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BLOT, WILLIAM J., SHRUBSOLE, MARTHA J. · 2016 to 2025
$22.0M
Proteomics of Hypertension and Alzheimer's Disease in African AmericansR01AG064950 · NIA · VANDERBILT UNIVERSITY · PI ROBINSON, RENA A. S. · 2019 to 2023
$4.1M
NCI NIH HHS U01 CA202979NIA NIH HHS R01 AG064950
6 · The paper itself

Abstract

Large-scale plasma proteomics studies have been transformed due to the multiplexing and automation of sample preparation workflows. However, these workflows can suffer from reproducibility issues, a lack of standardized quality control (QC) metrics, and the assessment of variation before liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis. The incorporation of robust QC metrics in sample preparation workflows ensures better reproducibility, lower assay variation, and better-informed decisions for troubleshooting. Our laboratory conducted a plasma proteomics study of a cohort of patient samples (

Identifiers

PMID39184360
PMCPMC11342454

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.