ArticleEpilepsy & behavior reports2024
The Epileptic Heart Syndrome: Epidemiology, pathophysiology and clinical detection.
Article in Epilepsy & behavior reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Electrocardiographic abnormalities in epilepsy: analysis of cardiac conduction patterns and SUDEP Risk.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Pooled it
- A price check on the ketogenic diet for adults with epilepsy in Australia.Epilepsia open · 2026Article
- Sudden unexpected death in epilepsy (SUDEP): Risk management of pediatric patients with epilepsy.Epilepsia open · 2026Article
- Cardiac-specific Kv1.1 deficiency alters cardiomyocyte electrophysiology without modifying overall cardiac function or arrhythmia susceptibility.Experimental physiology · 2026Article
- Cardiovascular morbidity following epilepsy: A nationwide retrospective cohort study in South Korea.Epilepsia open · 2026Article
- Areas of research priorities in epilepsy: A position paper of the European Reference Network for Rare and Complex Epilepsies, EpiCARE.Epilepsia open · 2026Article
- Pathophysiological frameworks and emerging preventative strategies in SUDEP.Frontiers in neurology · 2026Review
- Intersection of epilepsy and cardiac health: Insights from electrocardiography and syndromic associations.Epilepsia · 2025Review
- Epilepsy Care in the Real World of Multiple Medical Considerations.Epilepsy currents · 2025Review
- Epilepsy-heart syndrome: Concept, clinical context, and opportunity for integrated care.Epilepsia · 2025Article
- Management recommendations to reduce cardiac risk in chronic epilepsy.Epilepsy & behavior reports · 2025Review
- Cardiac abnormalities and repolarization variability in epilepsy: influence of antiseizure medications and treatment response.Frontiers in cardiovascular medicine · 2025Article
- There is no clear epileptic heart syndrome, but there are various cardiac complications following seizures.Epilepsy & behavior reports · 2024Article
- Response to Letter by J Finsterer MD.Epilepsy & behavior reports · 2024Article
- The brain-heart connection: Value of concurrent ECG and EEG recordings in epilepsy management.Epilepsy & behavior reports · 2024Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Population studies report elevated incidence of cardiovascular events in patients with chronic epilepsy. Multiple pathophysiologic processes have been implicated, including accelerated atherosclerosis, myocardial infarction, altered autonomic tone, heart failure, atrial and ventricular arrhythmias, and hyperlipidemia. These deleterious influences on the cardiovascular system have been attributed to seizure-induced surges in catecholamines and hypoxemic damage to the heart and coronary vasculature. Certain antiseizure medications can accelerate heart disease through enzyme-inducing increases in plasma lipids and/or increasing risk for life-threatening ventricular arrhythmias as a result of sodium channel blockade. In this review, we propose that this suite of pathophysiologic processes constitutes "The Epileptic Heart Syndrome." We further propose that this condition can be diagnosed using standard electrocardiography, echocardiography, and lipid panels. The ultimate goal of this syndromic approach is to evaluate cardiac risk in patients with chronic epilepsy and to promote improved diagnostic strategies to reduce premature cardiac death.
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