Evidence map›Paper›PMID 39184188›Full record

ArticleACS photonics2024

Miniaturized Head-Mount Doppler Optical Coherence Tomography Scope for Freely Moving Mouse.

Jingyi Wang, Qiao Ye, Lidek Chou, Saijun Qiu, Xiangmin Xu, Zhongping Chen

Abstract read
In one paragraph

Article in ACS photonics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jingyi WangBeckman Laser Institute, University of California Irvine, Irvine, California 92612, United States.ORCID https://orcid.org/0000-0002-8722-2401
Qiao YeDepartment of Biomedical Engineering, University of California Irvine, Irvine, California 92612, United States.
Lidek ChouBeckman Laser Institute, University of California Irvine, Irvine, California 92612, United States.
Saijun QiuBeckman Laser Institute, University of California Irvine, Irvine, California 92612, United States.
Xiangmin XuDepartment of Biomedical Engineering, University of California Irvine, Irvine, California 92612, United States.
Zhongping ChenBeckman Laser Institute, University of California Irvine, Irvine, California 92612, United States.ORCID https://orcid.org/0000-0002-4584-4560

Funding

Cell-type-specific neural circuit connectomes in the mouse models of aging and Alzheimer's diseaseU01AG076791 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Kim Green, ERAN A MUKAMEL · 2022 to 2026
$13.6M
Phase resolved ARF optical coherence elastography for intravascular imagingR01HL125084 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, ZHONGPING, ZHOU, QIFA · 2014 to 2023
$5.6M
High-resolution Elastographic Assessment of the Optic Nerve HeadR01EY028662 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, ZHONGPING, SIGAL, IAN A · 2018 to 2021
$2.7M
In vivo Imaging and Quantification of Cilia Beating Dynamics Using Phase-Resolved Optical Imaging TechnologyR01EB030024 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, ZHONGPING, WONG, BRIAN · 2020 to 2024
$2.3M
Continuous Monitoring and Management of Vaginal Health via Multifunctional OCT/OCTA EndoscopyR01EB030558 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, ZHONGPING, LANE, FELICIA LUCIA · 2021 to 2021
$1.9M
Customized cleared tissue light-sheet fluorescence microscope for imaging large brain samplesS10MH124715 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI XU, XIANGMIN · 2021 to 2021
$436k
NEI NIH HHS R01 EY028662NHLBI NIH HHS R01 HL125084NIA NIH HHS U01 AG076791NIBIB NIH HHS R01 EB030024NIBIB NIH HHS R01 EB030558NIMH NIH HHS S10 MH124715
6 · The paper itself

Abstract

This study presents a miniaturized head-mount optical coherence tomography (OCT) system tailored for high-resolution brain imaging in freely moving mice, providing an advanced noninvasive imaging tool in neuroscience research. Leveraging optical coherence tomography technology, the system enables depth-resolved imaging and integrates functional OCT extensions, including angiography and Doppler imaging. Remarkably lightweight at 1.5 g, the device allows for the preservation of natural mouse behavior during imaging sessions. With a maximum 4 × 4 mm field of view and 7.4 μm axial resolution, the system offers reliable imaging capabilities. Noteworthy features include focal adjustability, rotary joint integration for fiber-twist-free operation, and a high-speed swept-source OCT laser at 200 kHz, facilitating real-time imaging. By providing insights into brain mechanisms and neurological disorders without disrupting natural behavior, this innovative system holds promise as a powerful tool in neuroscience research. Its compact design and comprehensive imaging capabilities make it well-suited for studying various brain regions and dynamic processes, contributing significantly to our understanding of brain function and pathology.

Identifiers

PMID39184188
PMCPMC11342407

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.