Evidence map›Paper›PMID 39184178›Full record

ArticleNeurotrauma reports2024

Traumatic Brain Injury and Genetic Risk for Alzheimer's Disease Impact Cerebrospinal Fluid β-Amyloid Levels in Vietnam War Veterans.

Jena N Moody, Erica Howard, Kate E Nolan, Sarah Prieto, Mark W Logue, Jasmeet P Hayes, Alzheimer’s Disease Neuroimaging Initiative

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotrauma reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jena N MoodyDepartment of Psychology, The Ohio State University, Columbus, Ohio, USA.
Erica HowardDepartment of Psychology, The Ohio State University, Columbus, Ohio, USA.
Kate E NolanDepartment of Psychology, The Ohio State University, Columbus, Ohio, USA.
Sarah PrietoDepartment of Psychology, The Ohio State University, Columbus, Ohio, USA.
Mark W LogueNational Center for PTSD, VA Boston Healthcare System, Boston, Massachusetts, USA.
Jasmeet P HayesDepartment of Psychology, The Ohio State University, Columbus, Ohio, USA.ORCID https://orcid.org/0000-0002-5157-0666
Alzheimer’s Disease Neuroimaging Initiative

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Neuroimaging and Molecular Markers of AD and Neurodegenerative Disease after ConcussionR01AG058822 · NIA · OHIO STATE UNIVERSITY · PI Jasmeet Pannu Hayes · 2019 to 2026
$2.7M
NIA NIH HHS R01 AG058822NIA NIH HHS U01 AG024904
6 · The paper itself

Abstract

Traumatic brain injuries (TBIs) may increase the risk for Alzheimer's disease (AD) and its neuropathological correlates, although the mechanisms of this relationship are unclear. The current study examined the synergistic effects of TBI and genetic risk for AD on β-amyloid (Aβ) levels among Vietnam War Veterans. We hypothesized that the combination of TBI and higher polygenic risk score (PRS) for AD would be associated with lower cerebrospinal fluid (CSF) Aβ

Indexed as

Alzheimer’s diseasepolygenic risktraumatic brain injuryVietnam Veteransβ-amyloid

Identifiers

PMID39184178
PMCPMC11342050

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.