Evidence map›Paper›PMID 39184001›Full record

ArticleRSC advances2024

Development of a new experimental NMR strategy for covalent cysteine protease inhibitors screening: toward enhanced drug discovery.

Abdelali Chihab, Nabil El Brahmi, Ghanem Hamdoun, Abdelmoula El Abbouchi, Hamza Ghammaz, Nadia Touil, Mostafa Bousmina, Elmostafa El Fahime, Saïd El Kazzouli

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Abdelali ChihabEuromed University of Fes, UEMF Morocco s.elkazzouli@ueuromed.org.
Nabil El BrahmiEuromed University of Fes, UEMF Morocco s.elkazzouli@ueuromed.org.
Ghanem HamdounEuromed University of Fes, UEMF Morocco s.elkazzouli@ueuromed.org.
Abdelmoula El AbbouchiEuromed University of Fes, UEMF Morocco s.elkazzouli@ueuromed.org.
Hamza GhammazCentre National de la Recherche Scientifique et Technique (CNRST) Angle avenues des FAR et Allal El Fassi, Hay Ryad 10102 Rabat Morocco.
Nadia TouilCell Culture Unit, Center of Virology, Infectious, and Tropical Diseases Mohammed V Military Hospital Rabat Morocco.
Mostafa BousminaEuromed University of Fes, UEMF Morocco s.elkazzouli@ueuromed.org.
Elmostafa El FahimeCentre National de la Recherche Scientifique et Technique (CNRST) Angle avenues des FAR et Allal El Fassi, Hay Ryad 10102 Rabat Morocco.
Saïd El KazzouliEuromed University of Fes, UEMF Morocco s.elkazzouli@ueuromed.org.ORCID https://orcid.org/0000-0001-5021-3571

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the development of antiviral drugs, proteases and polymerases are among the most important targets. Cysteine proteases, also known as thiol proteases, catalyze the degradation of proteins by cleaving peptide bonds using the nucleophilic thiol group of cysteine. As part of our research, we are examining how cysteine, an essential amino acid found in the active site of the main protease (M

Identifiers

PMID39184001
PMCPMC11342919

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.