ArticleNature cardiovascular research2024
Disruption of the
Abstract read
In one paragraph
Article in Nature cardiovascular research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Review
- Genetic influences on haematopoiesis.Nature reviews. Genetics · 2026Review
- Coronary endothelial cells undergo venous-enriched disrupted maturation following myocardial infarction.Basic research in cardiology · 2026Article
- The ageing immune system as a driver of systemic ageing.Nature reviews. Immunology · 2026Review
- Mosaic loss of Y chromosome associates with lung function, emphysema, and epigenetic aging.American journal of respiratory and critical care medicine · 2026Article
- Loss of chromosome Y in hematopoietic cells: mechanisms and implications for human disease.MedScience · 2026Review
- Enhancer and metabolic rewiring by KMT2C-COMPASS or KMT2D-COMPASS family loss in cancer creates druggable vulnerabilities.Nature reviews. Cancer · 2026Review
- Sex Differences in Metabolite-Immune Circuits of Neuroinflammation.Immunological reviews · 2026Review
- Association of hematopoietic loss of Y chromosome with valvular heart disease incidence and sex susceptibility.Journal of advanced research · 2026Article
- The Immunological Consequences of Clonal Hematopoiesis in Heart Failure.Immunological reviews · 2026Review
- Epigenetic regulation of cardiac physiology and pathophysiology: biological sex matters.The journal of cardiovascular aging · 2026Article
- Article
- The spatial and temporal activation of macrophages during fibrosis.Nature reviews. Immunology · 2025Review
- Hematopoietic loss of Y chromosome activates immune checkpoints and contributes to impaired senescent cell clearance and renal disease.Science translational medicine · 2025Article
- Clonal Hematopoiesis in Cancer and Cardiovascular Disease: JACC: CardioOncology State-of-the-Art Review.JACC. CardioOncology · 2025Review
- Mosaic loss of chromosome Y in blood is associated with male susceptibility for idiopathic pulmonary fibrosis.Communications medicine · 2025Article
- Sex-dependent Pathophysiology and Therapeutic Considerations in Right Heart Disease.The Canadian journal of cardiology · 2025Review
- Contributions of Noncardiac Organ-Heart Immune Crosstalk and Somatic Mosaicism to Heart Failure: Current Knowledge and Perspectives.Circulation research · 2025Review
- The effects of loss of Y chromosome on male health.Nature reviews. Genetics · 2025Review
- Cardiac Fibrosis in the Multi-Omics Era: Implications for Heart Failure.Circulation research · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Keita HoritaniHematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, USA.
Nicholas W ChavkinHematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, USA.ORCID 0000-0001-9058-0245
Yohei AraiHematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, USA.
Ying WangHematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, USA.ORCID 0000-0002-6249-1859
Hayato OgawaHematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, USA.
Yoshimitsu YuraHematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, USA.
Megan A EvansHematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, USA.
Jesse D CochranHematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, USA.ORCID 0000-0001-9705-5785
Mark C ThelHematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, USA.ORCID 0000-0002-1512-6242
Ariel H PolizioHematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, USA.
Miho SanoHematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, USA.
Emiri Miura-YuraHematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, USA.ORCID 0000-0002-5477-5886
Yuka AraiHematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, USA.
Heather DoviakHematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, USA.
Arthur P ArnoldDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
Bradley D GelfandOphthalmology, Biomedical Engineering, Center for Advanced Vision Science (CAVS), University of Virginia School of Medicine, Charlottesville, VA, USA.
Karen K HirschiDepartment of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA, USA.ORCID 0000-0001-7116-0130
Soichi SanoHematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, USA.ORCID 0000-0002-3361-0839
Kenneth WalshHematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, USA.ORCID 0000-0001-7580-2276
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007267 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI GARCIA-BLANCO, MARIANO A. · 1985 to 2024
$13.4MVisual system and cognitive biology in normal animals versus in an animal model of Alzheimer's disease with or without diabetes treated with solo or dual inflammasome inhibitorsR01EY031039 · NEI · UNIVERSITY OF VIRGINIA · PI AMBATI, JAYAKRISHNA, GELFAND, BRADLEY DAVID · 2020 to 2024
$3.2MDefining the role of SINE retrotransposons and inflammasome activation in Alzheimer's diseaseR01AG078892 · NIA · UNIVERSITY OF VIRGINIA · PI Jayakrishna Ambati, Bradley David Gelfand · 2022 to 2026
$3.1MWnt signaling control of vascular phenotype in obesityR01HL142650 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI GOKCE, NOYAN, WALSH, KENNETH · 2019 to 2023
$3.1MMechanistic basis of sexual dimorphism in antigen-independent IgG1 angiogenesis regulationR01HL164592 · NHLBI · UNIVERSITY OF VIRGINIA · PI Bradley David Gelfand · 2023 to 2026
$2.7MMosaic loss of Y chromosome in blood and heart failureR01AG073249 · NIA · UNIVERSITY OF VIRGINIA · PI WALSH, KENNETH · 2021 to 2025
$2.6MRole of therapy-related clonal hematopoiesis in anthracycline-induced cardiotoxicityR01HL152174 · NHLBI · UNIVERSITY OF VIRGINIA · PI WALSH, KENNETH · 2020 to 2024
$2.0MNEI NIH HHS R01 EY031039NHLBI NIH HHS R01 HL142650NHLBI NIH HHS R01 HL152174NHLBI NIH HHS R01 HL164592NIA NIH HHS R01 AG073249NIA NIH HHS R01 AG078892NIGMS NIH HHS T32 GM007267
Abstract
Heart failure affects millions of people worldwide, with men exhibiting a higher incidence than women. Our previous work has shown that mosaic loss of the Y chromosome (LOY) in leukocytes is causally associated with an increased risk for heart failure. Here, we show that LOY macrophages from the failing hearts of humans with dilated cardiomyopathy exhibit widespread changes in gene expression that correlate with cardiac fibroblast activation. Moreover, we identify the ubiquitously transcribed t et ratricopeptide Y-linked (
Indexed as
Chromosomes, Human, YEpigenesis, GeneticHeart FailureAnimalsCardiomyopathy, DilatedCells, CulturedDisease Models, AnimalFemaleFibrosisHumansMacrophagesMaleMiceMice, Inbred C57BLMice, KnockoutMinor Histocompatibility AntigensMinor Histocompatibility AntigensProteinsUty protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.