Evidence map›Paper›PMID 39183928›Full record

ArticleChemical science2024

Unraveling mechanisms of protein encapsulation and release in coacervates

Yiwei Wang, Rongrong Zou, Yeqiang Zhou, Yi Zheng, Chuan Peng, Yang Liu, Hong Tan, Qiang Fu, Mingming Ding

Abstract read
PubMed Full text at PMC Publisher
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Article in Chemical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yiwei WangCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University Chengdu 610065 China liuyang_leon@scu.edu.cn dmmshx@scu.edu.cn dmmshx@163.com.
Rongrong ZouCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University Chengdu 610065 China liuyang_leon@scu.edu.cn dmmshx@scu.edu.cn dmmshx@163.com.
Yeqiang ZhouCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University Chengdu 610065 China liuyang_leon@scu.edu.cn dmmshx@scu.edu.cn dmmshx@163.com.
Yi ZhengCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University Chengdu 610065 China liuyang_leon@scu.edu.cn dmmshx@scu.edu.cn dmmshx@163.com.
Chuan PengCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University Chengdu 610065 China liuyang_leon@scu.edu.cn dmmshx@scu.edu.cn dmmshx@163.com.
Yang LiuCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University Chengdu 610065 China liuyang_leon@scu.edu.cn dmmshx@scu.edu.cn dmmshx@163.com.
Hong TanCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University Chengdu 610065 China liuyang_leon@scu.edu.cn dmmshx@scu.edu.cn dmmshx@163.com.ORCID https://orcid.org/0000-0003-0695-1619
Qiang FuCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University Chengdu 610065 China liuyang_leon@scu.edu.cn dmmshx@scu.edu.cn dmmshx@163.com.ORCID https://orcid.org/0000-0002-5191-3315
Mingming DingCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University Chengdu 610065 China liuyang_leon@scu.edu.cn dmmshx@scu.edu.cn dmmshx@163.com.ORCID https://orcid.org/0000-0003-2678-6307

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coacervates play a pivotal role in protein-based drug delivery research, yet their drug encapsulation and release mechanisms remain poorly understood. Here, we utilized the Martini model to investigate bovine serum albumin (BSA) protein encapsulation and release within polylysine/polyglutamate (PLys/PGlu) coacervates. Our findings emphasize the importance of ingredient addition sequence in coacervate formation and encapsulation rates, attributed to preference contact between oppositely charged proteins and poly(amino acid)s. Notably, coacervates composed of β-sheet poly(amino acid)s demonstrate greater BSA encapsulation efficiency due to their reduced entropy and flexibility. Furthermore, we examined the pH responsiveness of coacervates, shedding light on the dissolution process driven by Coulomb forces. By leveraging machine learning algorithms to analyze simulation results, our research advances the understanding of coacervate-based drug delivery systems, with the ultimate goal of optimizing therapeutic outcomes.

Identifiers

PMID39183928
PMCPMC11339950

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.